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  • Delayed olfactory ensheathing cell transplants reduce nociception after dorsal root injury

    Author(s)
    Wu, Ann
    Lauschke, Jenny L
    Gorrie, Catherine A
    Cameron, Nicholas
    Hayward, Ian
    Mackay-Sim, Alan
    Waite, Phil ME
    Griffith University Author(s)
    Cameron, Nicholas
    Mackay-Sim, Alan
    Hayward, Ian P.
    Year published
    2011
    Metadata
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    Abstract
    Injury to cervical dorsal roots mimics the deafferentation component of brachial plexus injury in humans, with intractable neuropathic pain in the deafferented limb being a common consequence. Such lesions are generally not amenable to surgical repair. The use of olfactory ensheathing cells (OECs) for dorsal root repair, via acute transplantation, has been successful in several studies. From a clinical point of view, delayed transplantation of OECs would provide a more realistic timeframe for repair. In this study we investigated the effect of delayed OEC transplantation on functional recovery of skilled forepaw movements ...
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    Injury to cervical dorsal roots mimics the deafferentation component of brachial plexus injury in humans, with intractable neuropathic pain in the deafferented limb being a common consequence. Such lesions are generally not amenable to surgical repair. The use of olfactory ensheathing cells (OECs) for dorsal root repair, via acute transplantation, has been successful in several studies. From a clinical point of view, delayed transplantation of OECs would provide a more realistic timeframe for repair. In this study we investigated the effect of delayed OEC transplantation on functional recovery of skilled forepaw movements and amelioration of neuropathic pain, using a C7 and C8 dorsal root injury rat model previously established in our lab. We found that OEC transplantation to the dorsal horn 1 week after root injury effectively attenuated neuropathic disturbances associated with dorsal root injury, including spontaneous pain behavior, tactile allodynia and thermal hyperalgesia. The sensory controls of complex, goal-oriented skilled reaching and ladder walking, however, were not improved by delayed OEC transplantation. We did not detect any significant influence of transplanted OECs on injury-induced central reorganisation and afferent sprouting. The anti-nociceptive effect mediated by OEC transplants may therefore be explained by alternative mechanisms such as modification of inflammation and astrogliosis. The significant effect of OEC transplants in mitigating neuropathic pain may be clinically useful in intractable pain syndromes arising from deafferentation.
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    Journal Title
    Experimental Neurology
    Volume
    229
    Issue
    1
    DOI
    https://doi.org/10.1016/j.expneurol.2010.07.006
    Subject
    Neurosciences not elsewhere classified
    Clinical Sciences
    Neurosciences
    Psychology
    Publication URI
    http://hdl.handle.net/10072/37165
    Collection
    • Journal articles

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