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dc.contributor.authorAl-Ankily, Mahmoud M.
dc.contributor.authorShamel, Mohamed
dc.contributor.authorBakr, Mahmoud
dc.date.accessioned2018-03-21T04:18:36Z
dc.date.available2018-03-21T04:18:36Z
dc.date.issued2018
dc.identifier.issn2347-2367
dc.identifier.urihttp://hdl.handle.net/10072/371958
dc.description.abstractDiabetes Mellitus (DM) has been associated with salivary glands dysfunction and disorders. Epidermal Growth Factor (EGF) is highly important in the process of wound healing in different parts of the body. The aim of the present study is to investigate the capacity of EGF to reverse the side effects of Streptozotocin (STZ) induced diabetes in the submandibular salivary glands of adult Albino male rats, through immunohistochemical localization of cytokeratin in the parenchyma of the glands. Sixty rats were used in this study and were divided into three equal groups, a control group, an STZ induced group and EGF group where STZ induced rats are treated with a daily EGF injection of a dose of 10 µg/Kg body weight for two months. The overall expression of cytokeratin in the submandibular salivary glands of STZ induced rats decreased significantly when compared to the control group. However, in EGF group, cytokeratin expression levels were restored to values that were nearly equal to normal levels. Daily intraperitoneal injection of epidermal growth factor in a dose of 10 µg/Kg body weight for two months, helped reverse the negative side effects of DM in STZ induced rats. However, a small amount of permanent damage was still evident. Future research will be conducted to confirm the above findings through immunohistochemical expression of myosin and E-cadherin as well as ultrastructural examination.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmber Publication
dc.publisher.urihttps://jrmds.in/index.php/JRMDS/article/view/416
dc.relation.ispartofpagefrom196
dc.relation.ispartofpageto203
dc.relation.ispartofissue1
dc.relation.ispartofjournalJournal of Research in Medical and Dental Science
dc.relation.ispartofvolume6
dc.subject.fieldofresearchOral Medicine and Pathology
dc.subject.fieldofresearchDental Therapeutics, Pharmacology and Toxicology
dc.subject.fieldofresearchcode110505
dc.subject.fieldofresearchcode110502
dc.titleEpidermal Growth Factor Restores Cytokeratin Expression in Rats with Diabetes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2018 Mahmoud M Bakr. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
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gro.griffith.authorBakr, Mahmoud


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