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  • Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson's Disease

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    Author(s)
    Morris, Rosie
    Lord, Sue
    Lawson, Rachael A
    Coleman, Shirley
    Galna, Brook
    Duncan, Gordon W
    Khoo, Tien K
    Yarnall, Alison J
    Burn, David J
    Rochester, Lynn
    Griffith University Author(s)
    Khoo, Tien Kheng
    Year published
    2017
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    Abstract
    Background: Dementia is significant in Parkinson’s disease (PD) with personal and socioeconomic impact. Early identification of risk is of upmost importance to optimize management. Gait precedes and predicts cognitive decline and dementia in older adults. We aimed to evaluate gait characteristics as predictors of cognitive decline in newly diagnosed PD. Methods: One hundred and nineteen participants recruited at diagnosis were assessed at baseline, 18 and 36 months. Baseline gait was characterized by variables that mapped to five domains: pace, rhythm, variability, asymmetry, and postural control. Cognitive assessment included ...
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    Background: Dementia is significant in Parkinson’s disease (PD) with personal and socioeconomic impact. Early identification of risk is of upmost importance to optimize management. Gait precedes and predicts cognitive decline and dementia in older adults. We aimed to evaluate gait characteristics as predictors of cognitive decline in newly diagnosed PD. Methods: One hundred and nineteen participants recruited at diagnosis were assessed at baseline, 18 and 36 months. Baseline gait was characterized by variables that mapped to five domains: pace, rhythm, variability, asymmetry, and postural control. Cognitive assessment included attention, fluctuating attention, executive function, visual memory, and visuospatial function. Mixed-effects models tested independent gait predictors of cognitive decline. Results: Gait characteristics of pace, variability, and postural control predicted decline in fluctuating attention and visual memory, whereas baseline neuropsychological assessment performance did not predict decline. Conclusions: This provides novel evidence for gait as a clinical biomarker for PD cognitive decline in early disease.
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    Journal Title
    Journals of Gerontology. Series A: Biological Sciences & Medical Sciences
    Volume
    72
    Issue
    12
    DOI
    https://doi.org/10.1093/gerona/glx071
    Copyright Statement
    © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Clinical sciences
    Clinical sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/371968
    Collection
    • Journal articles

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