Show simple item record

dc.contributor.authorMorris, Rosie
dc.contributor.authorLord, Sue
dc.contributor.authorLawson, Rachael A
dc.contributor.authorColeman, Shirley
dc.contributor.authorGalna, Brook
dc.contributor.authorDuncan, Gordon W
dc.contributor.authorKhoo, Tien K
dc.contributor.authorYarnall, Alison J
dc.contributor.authorBurn, David J
dc.contributor.authorRochester, Lynn
dc.date.accessioned2018-03-21T05:18:45Z
dc.date.available2018-03-21T05:18:45Z
dc.date.issued2017
dc.identifier.issn1079-5006
dc.identifier.doi10.1093/gerona/glx071
dc.identifier.urihttp://hdl.handle.net/10072/371968
dc.description.abstractBackground: Dementia is significant in Parkinson’s disease (PD) with personal and socioeconomic impact. Early identification of risk is of upmost importance to optimize management. Gait precedes and predicts cognitive decline and dementia in older adults. We aimed to evaluate gait characteristics as predictors of cognitive decline in newly diagnosed PD. Methods: One hundred and nineteen participants recruited at diagnosis were assessed at baseline, 18 and 36 months. Baseline gait was characterized by variables that mapped to five domains: pace, rhythm, variability, asymmetry, and postural control. Cognitive assessment included attention, fluctuating attention, executive function, visual memory, and visuospatial function. Mixed-effects models tested independent gait predictors of cognitive decline. Results: Gait characteristics of pace, variability, and postural control predicted decline in fluctuating attention and visual memory, whereas baseline neuropsychological assessment performance did not predict decline. Conclusions: This provides novel evidence for gait as a clinical biomarker for PD cognitive decline in early disease.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofpagefrom1656
dc.relation.ispartofpageto1662
dc.relation.ispartofissue12
dc.relation.ispartofjournalJournals of Gerontology. Series A: Biological Sciences & Medical Sciences
dc.relation.ispartofvolume72
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode1103
dc.titleGait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson's Disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorKhoo, Tien Kheng


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record