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dc.contributor.authorZheng, Junheng
dc.contributor.authorXu, Lixiao
dc.contributor.authorPan, Yubin
dc.contributor.authorYu, Shuyi
dc.contributor.authorWang, Hongbo
dc.contributor.authorKennedy, Derek
dc.contributor.authorZhang, Yan
dc.date.accessioned2018-03-22T00:11:40Z
dc.date.available2018-03-22T00:11:40Z
dc.date.issued2017
dc.identifier.issn1949-2553
dc.identifier.doi10.18632/oncotarget.21709
dc.identifier.urihttp://hdl.handle.net/10072/372003
dc.description.abstractSox2 (Sry-box2) is essential for a variety of stem cells and is also expressed in colorectal cancer (CRC). However, the underlying mechanism by which Sox2 enhances CRC progression remains unclear. In the present study, we show that elevated Sox2 expression is significantly correlated with poor clinical prognosis. CRC is phenotypically heterogeneous, and harbors several subtypes of cancer cells. Elevated Sox2 expression was always detected in rounded-shape cells, which co-located to poorly differentiated regions, the invasive frontier and metastatic lesions. Knockdown of Sox2 in CRC cells not only decreased the number of round-shaped cells, but also suppressed cell migration, invasion as well as attenuated colony forming capacity and tumorigenicity. By contrast, overexpression of Sox2 in CRC cells was associated with up-regulation of multidrug resistance genes and accelerated CRC progression. Moreover, Sox2 conferred activation of Rho-ROCK signaling, whereas inhibition of ROCK signaling decreased cell migration, invasion, colony formation and self-renewal of CRC. Our results reveal that CRC is phenotypically and functionally heterogeneous. Elevated Sox2 expression activates the Rho-ROCK pathway, which in turn changes cell morphology and promotes cell migration and progression.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherImpact Journals LLC
dc.relation.ispartofpagefrom98635
dc.relation.ispartofpageto98645
dc.relation.ispartofissue58
dc.relation.ispartofjournalOncotarget
dc.relation.ispartofvolume8
dc.subject.fieldofresearchOncology and Carcinogenesis not elsewhere classified
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode111299
dc.subject.fieldofresearchcode1112
dc.titleSox2 modulates motility and enhances progression of colorectal cancer via the Rho-ROCK signaling pathway
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by/3.0/
dc.description.versionPublished
gro.rights.copyright© Zheng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
gro.hasfulltextFull Text
gro.griffith.authorKennedy, Derek D.


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