Show simple item record

dc.contributor.authorBensch, K
dc.contributor.authorTiralongo, J
dc.contributor.authorMatthias, A
dc.contributor.authorBone, K
dc.contributor.authorLehmann, R
dc.contributor.authorTiralongo, E
dc.date.accessioned2017-05-03T14:35:21Z
dc.date.available2017-05-03T14:35:21Z
dc.date.issued2010
dc.date.modified2011-03-15T08:03:56Z
dc.identifier.issn0032-0943
dc.identifier.doi10.1055/s-0030-1264870
dc.identifier.urihttp://hdl.handle.net/10072/37257
dc.description.abstractCampylobacter jejuni is one of the most common bacterial causes of diarrhoea in the industrialised world [1], being associated with the occurrence of Guillain-Barr頓yndrome (GBS) [2] and induces diseases partially through intestinal adherence [3]. With increasing reports of C. jejuni drug resistance against standard antibiotics [4], investigations into anti-adhesive agents for the prevention of bacterial infection [5] are highly significant. Given the consumer-driven development towards holistic and integrative healthcare [6], research into additional anti-Campylobacter effects of phytotherapeutics that are already used for their beneficial effects on bowel and digestive functions is crucial. Dilutions of 21 herbal extracts were screened for anti-adhesive activity against C. jejuni using modifications of previously published anti-adhesion assays [7, 8]. Anti-adhesion effects with IC50 values <3mg/mL were obtained for 7 ethanolic plant extracts, with ginger, cayenne and licorice displaying the highest anti-adhesion activity against C. jejuni (IC50: <0.1mg/mL, 0.29mg/mL and 0.65mg/mL, respectively). Such marked activities could well be clinically relevant. In addition, differences in anti-adhesion activity were found for two different Echinacea species with E. purpurea displaying significantly higher and dose dependent anti-adhesion activity than E. pallida var. angustifolia. No significant anti-adhesion activity (IC50 values >35mg/mL) was found for agrimony, andrographis, chamomile, fennel, meadowsweet and wormwood extracts. This study provides evidence for additional beneficial effects of marketed phytotherapeutics in gastrointestinal disorders. Further research is required to identify i) synergistic effects of different herbal extracts, ii) anti-adhesive potential of as yet unknown compounds and iii) anti-adhesive activities of known herbal constituents.
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherThieme
dc.publisher.placeGermany
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofconferencename7th Tannin Conference/58th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research
dc.relation.ispartofconferencetitlePLANTA MEDICA
dc.relation.ispartofdatefrom2010-08-29
dc.relation.ispartofdateto2010-09-02
dc.relation.ispartoflocationBerlin, GERMANY
dc.relation.ispartofpagefrom1339
dc.relation.ispartofpagefrom1 pages
dc.relation.ispartofpageto1339
dc.relation.ispartofpageto1 pages
dc.relation.ispartofissue12
dc.relation.ispartofvolume76
dc.rights.retentionY
dc.subject.fieldofresearchPlant biology
dc.subject.fieldofresearchTraditional, complementary and integrative medicine
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchcode3108
dc.subject.fieldofresearchcode4208
dc.subject.fieldofresearchcode3214
dc.titleAnti-adhesive Activity of Herbal Extracts Against Campylobacter jejuni
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dc.type.codeE - Conference Publications
gro.facultyGriffith Health, School of Pharmacy
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorTiralongo, Joe
gro.griffith.authorTiralongo, Evelin


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Conference outputs
    Contains papers delivered by Griffith authors at national and international conferences.

Show simple item record