dc.contributor.author | Chan, Daniel Kam Yin | |
dc.contributor.author | Xu, Ying Hua | |
dc.contributor.author | Chan, Luke Kar Man | |
dc.contributor.author | Braidy, Nady | |
dc.contributor.author | Mellick, George D | |
dc.date.accessioned | 2018-11-19T12:31:29Z | |
dc.date.available | 2018-11-19T12:31:29Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 2047-9158 | |
dc.identifier.doi | 10.1186/s40035-017-0104-6 | |
dc.identifier.uri | http://hdl.handle.net/10072/372713 | |
dc.description.abstract | In this mini-review, we summarize recent findings relating to the prion-like propagation of α-synuclein (α-syn) and the development of novel therapeutic strategies to target synucleinopathy in Parkinson’s disease (PD). We link the Braak’s staging hypothesis of PD with the recent evidence from in-vivo and in-vitro studies for the prion-like cell-to-cell propagation of α-syn (via exocytosis and endocytosis). The classical accumulation of aggregated α-syn in PD may result from an increased production or a failure in the mechanisms of clearance of α-syn. We discuss novel agents, currently in clinical trial for PD including the ones that impact the aggregation of α-syn and others that interfere with α-syn endocytosis as a means to target the progression of the disease. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | BioMed Central Ltd. | |
dc.relation.ispartofpagefrom | 33-1 | |
dc.relation.ispartofpageto | 33-5 | |
dc.relation.ispartofjournal | Translational Neurodegeneration | |
dc.relation.ispartofvolume | 6 | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearch | Clinical sciences not elsewhere classified | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.fieldofresearchcode | 320299 | |
dc.title | Mini-review on initiatives to interfere with the propagation and clearance of alpha-synuclein in Parkinson’s disease | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dc.description.version | Version of Record (VoR) | |
gro.description.notepublic | Page numbers are not for citation purposes. Instead, this article has the unique article number of 33. | |
gro.rights.copyright | © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Mellick, George | |