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dc.contributor.authorChan, Daniel Kam Yin
dc.contributor.authorXu, Ying Hua
dc.contributor.authorChan, Luke Kar Man
dc.contributor.authorBraidy, Nady
dc.contributor.authorMellick, George D
dc.date.accessioned2018-11-19T12:31:29Z
dc.date.available2018-11-19T12:31:29Z
dc.date.issued2017
dc.identifier.issn2047-9158
dc.identifier.doi10.1186/s40035-017-0104-6
dc.identifier.urihttp://hdl.handle.net/10072/372713
dc.description.abstractIn this mini-review, we summarize recent findings relating to the prion-like propagation of α-synuclein (α-syn) and the development of novel therapeutic strategies to target synucleinopathy in Parkinson’s disease (PD). We link the Braak’s staging hypothesis of PD with the recent evidence from in-vivo and in-vitro studies for the prion-like cell-to-cell propagation of α-syn (via exocytosis and endocytosis). The classical accumulation of aggregated α-syn in PD may result from an increased production or a failure in the mechanisms of clearance of α-syn. We discuss novel agents, currently in clinical trial for PD including the ones that impact the aggregation of α-syn and others that interfere with α-syn endocytosis as a means to target the progression of the disease.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central Ltd.
dc.relation.ispartofpagefrom33-1
dc.relation.ispartofpageto33-5
dc.relation.ispartofjournalTranslational Neurodegeneration
dc.relation.ispartofvolume6
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchClinical sciences not elsewhere classified
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode320299
dc.titleMini-review on initiatives to interfere with the propagation and clearance of alpha-synuclein in Parkinson’s disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.description.notepublicPage numbers are not for citation purposes. Instead, this article has the unique article number of 33.
gro.rights.copyright© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
gro.hasfulltextFull Text
gro.griffith.authorMellick, George


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