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dc.contributor.authorBuedenbender, Larissa
dc.contributor.authorCarroll, Anthony R
dc.contributor.authorEkins, Merrick
dc.contributor.authorKurtboke, D Ipek
dc.date.accessioned2018-04-04T02:28:11Z
dc.date.available2018-04-04T02:28:11Z
dc.date.issued2017
dc.identifier.issn1424-2818
dc.identifier.doi10.3390/d9040053
dc.identifier.urihttp://hdl.handle.net/10072/372842
dc.description.abstractActinomycetes are known to be the most prolific producers of biologically active metabolites. Here, we investigated the host species-specificity and the related secondary metabolites of actinomycetes that are associated with three different Australian ascidians, namely Symplegma rubra, Aplidium solidum, and Polyclinum vasculosum. Results indicated that while isolates from the genera Streptomyces and Micromonospora were highly diverse in the ascidian samples, only two culturable actinomycete Operational Taxonomic Units (OTUs) overlapped between all of the ascidians, pointing to some degree of host species-specificity of the isolates and selective acquisition of microbial associates by the host from the surrounding environment. LC-MS/MS profiling of extracts obtained from the ascidians and their actinomycete associates revealed many overlapping ions between hosts and actinomycetes, indicating that these compounds were likely to be synthesised by the microbial associates. Laboratory cultures of the actinomycetes displayed even more diverse metabolomes than those of their ascidian hosts; thus, making ascidian-associated actinomycetes an excellent target for natural product drug discovery and biotechnology.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherM D P I AG
dc.relation.ispartofpagefrom53-1
dc.relation.ispartofpageto53-18
dc.relation.ispartofissue4
dc.relation.ispartofjournalDiversity
dc.relation.ispartofvolume9
dc.subject.fieldofresearchEcology not elsewhere classified
dc.subject.fieldofresearchAnalytical Chemistry
dc.subject.fieldofresearchDistributed Computing
dc.subject.fieldofresearchElectrical and Electronic Engineering
dc.subject.fieldofresearchEnvironmental Science and Management
dc.subject.fieldofresearchEcology
dc.subject.fieldofresearchcode060299
dc.subject.fieldofresearchcode0301
dc.subject.fieldofresearchcode0805
dc.subject.fieldofresearchcode0906
dc.subject.fieldofresearchcode0502
dc.subject.fieldofresearchcode0602
dc.titleTaxonomic and Metabolite Diversity of Actinomycetes Associated with Three Australian Ascidians
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionPublished
gro.facultyGriffith Sciences, Griffith School of Environment
gro.rights.copyright© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorCarroll, Anthony R.
gro.griffith.authorBuedenbender, Larissa
gro.griffith.authorEkins, Merrick


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