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dc.contributor.authorIrani, Soussan
dc.contributor.authorBidari-Zerehpoush, Farahnaz
dc.date.accessioned2018-07-23T12:30:37Z
dc.date.available2018-07-23T12:30:37Z
dc.date.issued2017
dc.identifier.issn2231-0762
dc.identifier.doi10.4103/jispcd.JISPCD_184_17
dc.identifier.urihttp://hdl.handle.net/10072/372976
dc.description.abstractObjectives: It is hypothesized that carcinoma-ex-pleomorphic adenoma (Ca-ex-PA) is malignant from the beginning or is a malignant transformation of a recurrent or a long-standing pleomorphic adenoma (PA). The accumulation of genetic instabilities is suggested to be the main reason for malignant transformation in PA. The aim of this study was to determine the prevalence of BRCA1/2 mutations in PA and Ca-ex-PA. Materials and Methods: A total of ninety salivary gland tumors (45 Ca ex-PA and 45 PA) were selected. Immunohistochemistry was performed for all samples. Analyses were conducted through SPSS software version 22.0 (SPSS, Inc., Chicago, IL, USA). Chi-square test was used to examine the differences between the variables. Significant level was set at 0.05. Results: In general, 93.3% of PA samples showed positive staining for BRCA1 (in myoepithelial cells); however, BRCA2 positivity was found in 60% of samples (in myoepithelial cells). Among 45 samples of Ca-ex-PA, 93.3% of showed positivity for BRCA1 and 80% of samples showed positivity for BRCA2. Chi-square test found differences between PAs and Ca-ex-PAs regarding BRCA1/2 mutations in ductal cells and myoepithelial cells (P = 0.007, 0.000), respectively. Conclusions: The present study found a trend toward the presence of BRCA1/2 mutations in PA and Ca-ex-PA samples. Patients with BRCA1/2 mutation carriers are excellent cases for therapies, such as the poly (ADP) ribose polymerase inhibitor.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMedknow Publications and Media Pvt. Ltd.
dc.relation.ispartofpagefrom155
dc.relation.ispartofpageto162
dc.relation.ispartofissue9
dc.relation.ispartofjournalJournal of International Society of Preventive and Community Dentistry
dc.relation.ispartofvolume7
dc.subject.fieldofresearchDentistry not elsewhere classified
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchcode110599
dc.subject.fieldofresearchcode1105
dc.titleBRCA1/2 mutations in salivary pleomorphic adenoma and carcinoma-ex-pleomorphic adenoma
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by-nc-sa/3.0/
dc.description.versionVersion of Record (VoR)
gro.facultyGriffith Health, School of Medicine
gro.rights.copyright© The Author(s) 2017. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
gro.hasfulltextFull Text
gro.griffith.authorIrani, Soussan


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