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dc.contributor.authorSteinbuchel, A
dc.contributor.authorFuchtenbusch, B
dc.contributor.authorGorenflo, V
dc.contributor.authorHein, S
dc.contributor.authorJossek, R
dc.contributor.authorLangenbach, S
dc.contributor.authorRehm, BHA
dc.date.accessioned2018-04-11T05:06:22Z
dc.date.available2018-04-11T05:06:22Z
dc.date.issued1998
dc.identifier.issn0141-3910
dc.identifier.urihttp://hdl.handle.net/10072/372978
dc.description.abstractMany bacteria are able to synthesize polyesters of hydroxyalkanoic acids (PHA), which occur as insoluble cytoplasmic inclusions in the cell and can contribute significantly to the cellular dry matter. More than 100 different hydroxyalkanoic acids have been detected as constituents in PHA. This article summarizes strategies and possibilities to obtain these biodegradable and thermoplastic/elastomeric polymers by fermentation of wild-type bacteria as well as of mutants and recombinant strains from renewable resources, waste substrates or special precursor substrates. In addition,in vitro biosynthesis of PHA employing the purified polymerizing enzyme (PHA synthase) is described. Throughout analysis and cloning of the bacterial PHA biosynthesis genes enabled scientists to also establish this pathway in non-PHA producing eukaryotic organisms such as yeast, plants and animals. This will allow new processes for cheap and economic production of PHA.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier Ltd
dc.relation.ispartofpagefrom177
dc.relation.ispartofpageto182
dc.relation.ispartofissue1-3
dc.relation.ispartofjournalPolymer Degradation and Stability
dc.relation.ispartofvolume59
dc.subject.fieldofresearchMacromolecular and Materials Chemistry not elsewhere classified
dc.subject.fieldofresearchMacromolecular and Materials Chemistry
dc.subject.fieldofresearchChemical Engineering
dc.subject.fieldofresearchMaterials Engineering
dc.subject.fieldofresearchcode030399
dc.subject.fieldofresearchcode0303
dc.subject.fieldofresearchcode0904
dc.subject.fieldofresearchcode0912
dc.titleBiosynthesis of polyesters in bacteria and recombinant organisms
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorRehm, Bernd


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