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dc.contributor.authorSteinbuchel, Alexander
dc.contributor.authorFuchtenbusch, Bernd
dc.contributor.authorGorenflo, Volker
dc.contributor.authorHein, Silke
dc.contributor.authorJossek, Ralf
dc.contributor.authorLangenbach, Stefan
dc.contributor.authorRehm, Bernd H.A.
dc.description.abstractMany bacteria are able to synthesize polyesters of hydroxyalkanoic acids (PHA), which occur as insoluble cytoplasmic inclusions in the cell and can contribute significantly to the cellular dry matter. More than 100 different hydroxyalkanoic acids have been detected as constituents in PHA. This article summarizes strategies and possibilities to obtain these biodegradable and thermoplastic/elastomeric polymers by fermentation of wild-type bacteria as well as of mutants and recombinant strains from renewable resources, waste substrates or special precursor substrates. In addition,in vitro biosynthesis of PHA employing the purified polymerizing enzyme (PHA synthase) is described. Throughout analysis and cloning of the bacterial PHA biosynthesis genes enabled scientists to also establish this pathway in non-PHA producing eukaryotic organisms such as yeast, plants and animals. This will allow new processes for cheap and economic production of PHA.en_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofjournalPolymer Degradation and Stabilityen_US
dc.subject.fieldofresearchMacromolecular and Materials Chemistry not elsewhere classifieden_US
dc.titleBiosynthesis of polyesters in bacteria and recombinant organismsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.hasfulltextNo Full Text

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