Show simple item record

dc.contributor.authorTomasetti, Marco
dc.contributor.authorLee, Wan
dc.contributor.authorSantarelli, Lory
dc.contributor.authorNeuzil, Jiri
dc.date.accessioned2018-04-12T00:56:52Z
dc.date.available2018-04-12T00:56:52Z
dc.date.issued2017
dc.identifier.issn1226-3613
dc.identifier.doi10.1038/emm.2016.153
dc.identifier.urihttp://hdl.handle.net/10072/373028
dc.description.abstractMalignant progression is greatly affected by dynamic cross-talk between stromal and cancer cells. Exosomes are secreted nanovesicles that have key roles in cell–cell communication by transferring nucleic acids and proteins to target cells and tissues. Recently, MicroRNAs (miRs) and their delivery in exosomes have been implicated in physiological and pathological processes. Tumor-delivered miRs, interacting with stromal cells in the tumor microenvironment, modulate tumor progression, angiogenesis, metastasis and immune escape. Altered cell metabolism is one of the hallmarks of cancer. A number of different types of tumor rely on mitochondrial metabolism by triggering adaptive mechanisms to optimize their oxidative phosphorylation in relation to their substrate supply and energy demands. Exogenous exosomes can induce metabolic reprogramming by restoring the respiration of cancer cells and supress tumor growth. The exosomal miRs involved in the modulation of cancer metabolism may be potentially utilized for better diagnostics and therapy.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofpagefrome285-1
dc.relation.ispartofpagetoe285-11
dc.relation.ispartofjournalExperimental & Molecular Medicine
dc.relation.ispartofvolume49
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchEnvironmental biotechnology not elsewhere classified
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode410399
dc.titleExosome-derived microRNAs in cancer metabolism: Possible implications in cancer diagnostics and therapy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Authors 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
gro.hasfulltextFull Text
gro.griffith.authorNeuzil, Jiri


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record