• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Does ethnicity influence fractional exhaled nitric oxide in healthy individuals? A systematic review

    Author(s)
    Blake, Tamara L
    Chang, Anne B
    Chatfield, Mark D
    Petsky, Helen L
    Rodwell, Leanne T
    Brown, Michael G
    Hill, Deb C
    McElrea, Margaret S
    Griffith University Author(s)
    Petsky, Helen
    Year published
    2017
    Metadata
    Show full item record
    Abstract
    BACKGROUND: Fractional exhaled nitric oxide (FENO) is used clinically as a biomarker of eosinophilic airway inflammation. Awareness of the factors influencing FENO values is important for valid clinical interpretation. METHODS: We undertook a systematic review of PubMed, Cochrane Library, Scopus, and Web of Science databases and reference lists of included articles to evaluate whether ethnicity influences FENO values, and to determine if this influence affects clinical interpretation according to current guidelines. We included all studies that performed online FENO measurements on at least 25 healthy, non-Caucasian individuals, ...
    View more >
    BACKGROUND: Fractional exhaled nitric oxide (FENO) is used clinically as a biomarker of eosinophilic airway inflammation. Awareness of the factors influencing FENO values is important for valid clinical interpretation. METHODS: We undertook a systematic review of PubMed, Cochrane Library, Scopus, and Web of Science databases and reference lists of included articles to evaluate whether ethnicity influences FENO values, and to determine if this influence affects clinical interpretation according to current guidelines. We included all studies that performed online FENO measurements on at least 25 healthy, non-Caucasian individuals, and examined the effect of ethnicity on FENO. RESULTS: From 62 potential studies, 12 studies were included. One study recruited only children (< 12 years of age), six studies recruited children and/or adolescents, four studies recruited adults only, and a single study involved children, adolescents, and adults. In total, 16 different ethnic populations representing 11 ethnicities were studied. Ethnicity was considered a significant influencing factor in 10 of the included studies. We found the geometric mean FENO to be above the normal healthy range in two studies. We also identified five studies in which at least 5% of participants had FENO results above the age-specific inflammatory ranges. CONCLUSIONS: Ethnicity influences FENO values, and for some ethnic groups this influence likely affects clinical interpretation according to current guidelines. There is a need to establish healthy FENO reference ranges for specific ethnic groups to improve clinical application.
    View less >
    Journal Title
    Chest
    Volume
    152
    Issue
    1
    DOI
    https://doi.org/10.1016/j.chest.2017.02.007
    Subject
    Clinical sciences
    Publication URI
    http://hdl.handle.net/10072/373365
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E
    • TEQSA: PRV12076

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander