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dc.contributor.authorLi, Ping
dc.contributor.authorYang, Xiangyun
dc.contributor.authorGreenshaw, Andrew J
dc.contributor.authorLi, Sufang
dc.contributor.authorLuo, Jia
dc.contributor.authorHan, Haiying
dc.contributor.authorLiu, Jing
dc.contributor.authorZhong, Zhaoxi
dc.contributor.authorGuo, Zhihua
dc.contributor.authorXiong, Hongfang
dc.contributor.authorYao, Shumin
dc.contributor.authorChen, Yunhui
dc.contributor.authorSun, Jing
dc.contributor.authorLi, Zhanjiang
dc.date.accessioned2019-05-29T13:01:38Z
dc.date.available2019-05-29T13:01:38Z
dc.date.issued2018
dc.identifier.issn2162-3279
dc.identifier.doi10.1002/brb3.963
dc.identifier.urihttp://hdl.handle.net/10072/373625
dc.description.abstractObjectives: Although cognitive behavioral therapy (CBT) is an effective treatment for obsessive–compulsive disorder (OCD), the treatment mechanisms remain poorly understood. This study aimed to investigate the effects of CBT on changes in the intrinsic whole-brain functional network of OCD patients. Materials and Methods: Twenty drug-naive and noncomorbid OCD patients were recruited, and resting-state functional magnetic resonance imaging was performed before and after 12 weeks of CBT. Moreover, 20 healthy controls were scanned twice with a 12-week interval. A graph-theory degree centrality (DC) approach and functional connectivity method were used to analyze the whole-brain functional network hub and connectivity changes in OCD patients before and after CBT treatment. Results: A significant group × time interaction on DC was found in the left dorsolateral prefrontal cortex (DLPFC); the DC in the left DLPFC was significantly reduced after CBT treatment. Resting-state functional connectivity (RSFC) between the left DLPFC and right orbitofrontal cortex was increased in the OCD patients at baseline, and normalized after CBT treatment. RSFC changes between the left DLPFC and default mode network (DMN) positively correlated with changes in clinical symptoms in OCD patients. Conclusions: These findings suggest that CBT can modulate changes in intrinsic functional network hubs in the cortico–striato–thalamo-cortical circuit in OCD patients. Cognitive control network and DMN connectivity may be a potential imaging biomarker for evaluating CBT treatment for OCD.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto13
dc.relation.ispartofjournalBrain and Behavior
dc.relation.ispartofvolume2018
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchNeurosciences not elsewhere classified
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchBiological psychology
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode320999
dc.subject.fieldofresearchcode52
dc.subject.fieldofresearchcode5204
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode5202
dc.titleThe effects of cognitive behavioral therapy on resting-state functional brain network in drug-naive patients with obsessive-compulsive disorder
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.rights.copyright© 2018 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorSun, Jing


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