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  • Systematic evaluation of self-adjuvanting lipopeptide nano-vaccine platforms for the induction of potent CD8+ T-cell responses

    Author(s)
    Apte, Simon H
    Stephenson, Rachel J
    Simerska, Pavla
    Groves, Penny L
    Aljohani, Salwa
    Eskandari, Sharareh
    Toth, Istvan
    Doolan, Denise L
    Griffith University Author(s)
    Eskandari, Sherry
    Year published
    2016
    Metadata
    Show full item record
    Abstract
    Aim: Systematically evaluate lipid core peptide vaccine delivery platforms to identify core features promoting strong CD8+ T-cell responses. Materials & methods: Three different self-adjuvanting lipid core peptide nanovaccines each comprising four copies of the dominant ovalbumin CD8+ T-cell epitope and varying in the utilization of a polylysine or glucose core with 2-amino-hexadecanoic acid (C16) or 2-amino-dodecanoic acid (C12) lipids were synthesized. Vaccines were tested for ability to induce CD8+ T-cell responses and inhibit tumor growth in vivo. Results: The construct utilizing C12 lipids and polylysine core induced ...
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    Aim: Systematically evaluate lipid core peptide vaccine delivery platforms to identify core features promoting strong CD8+ T-cell responses. Materials & methods: Three different self-adjuvanting lipid core peptide nanovaccines each comprising four copies of the dominant ovalbumin CD8+ T-cell epitope and varying in the utilization of a polylysine or glucose core with 2-amino-hexadecanoic acid (C16) or 2-amino-dodecanoic acid (C12) lipids were synthesized. Vaccines were tested for ability to induce CD8+ T-cell responses and inhibit tumor growth in vivo. Results: The construct utilizing C12 lipids and polylysine core induced very robust effector T cells shown to have in vivo effector capability as demonstrated by in vivo cytotoxicity and ability to inhibit tumor growth as well as modulation of dendritic cell activation. Conclusion: The C12 polylysine platform was an effective configuration for induction of potent CD8+ T-cell responses.
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    Journal Title
    Nanomedicine
    Volume
    11
    Issue
    2
    DOI
    https://doi.org/10.2217/nnm.15.184
    Subject
    Physical chemistry
    Medical biotechnology
    Medical biotechnology not elsewhere classified
    Nanotechnology
    Publication URI
    http://hdl.handle.net/10072/373777
    Collection
    • Journal articles

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