Show simple item record

dc.contributor.authorMirshafiey, Abbas
dc.contributor.authorRehm, Bernd H.A.
dc.contributor.editorBernd H.A. Rehm
dc.date.accessioned2018-04-26T01:53:07Z
dc.date.available2018-04-26T01:53:07Z
dc.date.issued2009
dc.identifier.isbn9783540926788
dc.identifier.doi10.1007/978-3-540-92679-5_10
dc.identifier.urihttp://hdl.handle.net/10072/373801
dc.description.abstractThe therapeutic and anti-inflammatory properties of sodium alginate and one of its components, β-d-mannuronic acid, were tested in various experimental models. On the basis of its chemical structure, β-d-mannuronic acid had been conceived as an anti-inflammatory drug. β-d-Mannuronic acid is a constituent of alginate but is not available commercially; hence, polymannuronate was obtained from an epimerase (AlgG) negative mutant of Pseudomonas sp. and the monomer was isolated by acid hydrolysis. The oral and intraperitoneal administration of alginate gels in experimental models of ulcerative colitis and glomerulonephritis as well as the oral administration and intraperitoneal injections of β-d-mannuronic acid in different models of rheumatoid arthritis, multiple sclerosis, glomerulonephritis, and nephrotic syndrome showed that alginate as well as β-d-mannuronic acid are able to exhibit their therapeutic efficacy in inflammatory diseases. Recent experimental evidence has revealed that β-d-mannuronic acid represents a novel nonsteroidal anti-inflammatory drug with a low molecular weight and which provides a new therapeutic option in attenuation of inflammatory reactions and autoimmune diseases.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeGermany
dc.relation.ispartofbooktitleAlginates: Biology and Applications
dc.relation.ispartofchapter10
dc.relation.ispartofpagefrom229
dc.relation.ispartofpageto260
dc.relation.ispartofedition1st
dc.relation.ispartofvolume13
dc.subject.fieldofresearchBiochemistry and cell biology not elsewhere classified
dc.subject.fieldofresearchcode310199
dc.titleAlginate and Its Comonomer Mannuronic Acid: Medical Relevance as Drugs
dc.typeBook chapter
dc.type.descriptionB1 - Chapters
dc.type.codeB - Book Chapters
gro.hasfulltextNo Full Text
gro.griffith.authorRehm, Bernd


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Book chapters
    Contains book chapters authored by Griffith authors.

Show simple item record