dc.contributor.author | Grage, Katrin | |
dc.contributor.author | Peters, Verena | |
dc.contributor.author | Palanisamy, Rajasekaran | |
dc.contributor.author | Rehm, Bernd H.A. | |
dc.contributor.editor | Bernd H.A. Rehm | |
dc.date.accessioned | 2018-07-03T01:30:25Z | |
dc.date.available | 2018-07-03T01:30:25Z | |
dc.date.issued | 2009 | |
dc.identifier.isbn | 9781904455363 | |
dc.identifier.uri | http://hdl.handle.net/10072/373804 | |
dc.description.abstract | Polyhydroxyalkanoates (PHAs) are organic polyesters composed of (R)-3-hydroxy fatty acids which are synthesized by many bacteria as a carbon and energy storage material in times of unbalanced nutrient availability. They are deposited intracellularly as insoluble spherical inclusions called PHA granules which consist of a polyester core surrounded by a phospholipid layer with attached proteins. One of these proteins is the PHA synthase, the key enzyme of PHA biosynthesis, which catalyses polyester formation from different (R)-3-hydroxyacyl-CoA precursors. The PHA synthase remains covalently attached to the polyester and thus to the PHA granule; other granule-associated proteins are involved in depolymerization, regulation or structural stabilization. This chapter provides a comprehensive overview of the current understanding of PHAs and PHA granules, including granule biogenesis and granule-associated proteins. In recent years, apart from investigating in particular the granule self-assembly process and the function of granule-associated proteins, a lot of research interest has been focused on the usability of this natural system. Accordingly, this review will also give an overview of metabolic engineering and large-scale production approaches, and discuss applications of PHAs as biocompatible and biodegradable plastics as well as the potential applicability of PHA granules as micro-/nano-beads. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Caister Academic Press | |
dc.publisher.place | United Kingdom | |
dc.publisher.uri | https://www.caister.com/biopolymers | |
dc.relation.ispartofbooktitle | Microbial production of biopolymers and polymer precursors: applications and perspectives | |
dc.relation.ispartofchapter | 11 | |
dc.relation.ispartofpagefrom | 255 | |
dc.relation.ispartofpageto | 288 | |
dc.relation.ispartofedition | 1st | |
dc.relation.ispartofvolume | 1 | |
dc.subject.fieldofresearch | Biochemistry and Cell Biology not elsewhere classified | |
dc.subject.fieldofresearchcode | 060199 | |
dc.title | Polyhydroxyalkanoates: From Bacterial Storage Compound via Renewable Plastic to Bio-Bead | |
dc.type | Book chapter | |
dc.type.description | B1 - Chapters | |
dc.type.code | B - Book Chapters | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Rehm, Bernd | |