Show simple item record

dc.contributor.authorGrage, Katrin
dc.contributor.authorPeters, Verena
dc.contributor.authorPalanisamy, Rajasekaran
dc.contributor.authorRehm, Bernd H.A.
dc.contributor.editorBernd H.A. Rehm
dc.description.abstractPolyhydroxyalkanoates (PHAs) are organic polyesters composed of (R)-3-hydroxy fatty acids which are synthesized by many bacteria as a carbon and energy storage material in times of unbalanced nutrient availability. They are deposited intracellularly as insoluble spherical inclusions called PHA granules which consist of a polyester core surrounded by a phospholipid layer with attached proteins. One of these proteins is the PHA synthase, the key enzyme of PHA biosyn­thesis, which catalyses polyester formation from different (R)-3-hydroxyacyl-CoA precursors. The PHA synthase remains covalently attached to the polyester and thus to the PHA granule; other granule-associated proteins are involved in depolymerization, regulation or structural stabilization. This chapter provides a comprehensive overview of the current understanding of PHAs and PHA granules, including granule biogenesis and granule-associated proteins. In recent years, apart from investigating in particular the granule self-assembly process and the function of gran­ule-associated proteins, a lot of research interest has been focused on the usability of this natural system. Accordingly, this review will also give an overview of metabolic engineering and large-scale production approaches, and discuss applications of PHAs as biocompatible and biodegradable plastics as well as the potential applicability of PHA granules as micro-/nano-beads.
dc.publisherCaister Academic Press
dc.publisher.placeUnited Kingdom
dc.relation.ispartofbooktitleMicrobial production of biopolymers and polymer precursors: applications and perspectives
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classified
dc.titlePolyhydroxyalkanoates: From Bacterial Storage Compound via Renewable Plastic to Bio-Bead
dc.typeBook chapter
dc.type.descriptionB1 - Chapters
dc.type.codeB - Book Chapters
gro.hasfulltextNo Full Text
gro.griffith.authorRehm, Bernd

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

  • Book chapters
    Contains book chapters authored by Griffith authors.

Show simple item record