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dc.contributor.authorZhang, Pingen_US
dc.contributor.authorGeorgiou, Constantinos Aen_US
dc.contributor.authorBrusic, Vladimiren_US
dc.date.accessioned2018-06-19T01:30:19Z
dc.date.available2018-06-19T01:30:19Z
dc.date.issued2017en_US
dc.identifier.issn1477-4054en_US
dc.identifier.doi10.1093/bib/bbw131en_US
dc.identifier.urihttp://hdl.handle.net/10072/374200
dc.description.abstractElemental metabolomics is quantification and characterization of total concentration of chemical elements in biological samples and monitoring of their changes. Recent advances in inductively coupled plasma mass spectrometry have enabled simultaneous measurement of concentrations of > 70 elements in biological samples. In living organisms, elements interact and compete with each other for absorption and molecular interactions. They also interact with proteins and nucleotide sequences. These interactions modulate enzymatic activities and are critical for many molecular and cellular functions. Testing for concentration of > 40 elements in blood, other bodily fluids and tissues is now in routine use in advanced medical laboratories. In this article, we define the basic concepts of elemental metabolomics, summarize standards and workflows, and propose minimum information for reporting the results of an elemental metabolomics experiment. Major statistical and informatics tools for elemental metabolomics are reviewed, and examples of applications are discussed. Elemental metabolomics is emerging as an important new technology with applications in medical diagnostics, nutrition, agriculture, food science, environmental science and multiplicity of other areas.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto13en_US
dc.relation.ispartofjournalBriefings in Bioinformaticsen_US
dc.subject.fieldofresearchMetabolic Medicineen_US
dc.subject.fieldofresearchcode110107en_US
dc.titleElemental metabolomicsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
dc.description.versionPost-printen_US
gro.facultyGriffith Health, Menzies Health Instituteen_US
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.en_US
gro.rights.copyright© 2017 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Briefings in Bioinformatics following peer review. The definitive publisher-authenticated version Elemental metabolomics, Briefings in Bioinformatics, is available online at: DOI 10.1093/bib/bbw131.en_US
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