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  • Chemical constituents from Sophora tonkinensis and their glucose transporter 4 translocation activities

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    Author(s)
    Yang, Xinzhou
    Deng, Shihao
    Huang, Mi
    Wang, Jialin
    Chen, Li
    Xiong, Mingrui
    Yang, Jie
    Zheng, Sijiang
    Ma, Xinhua
    Zhao, Ping
    Feng, Yunjiang
    Griffith University Author(s)
    Feng, Yun J.
    Year published
    2017
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    Abstract
    Bioassay-guided phytochemical investigation of the EtOAc fraction (ST-EtOAc) from the roots of Sophora tonkinensis resulted in the isolation of a new compound 6aR,11aR-1-hydroxy-4-isoprenyl-maackiain (1), along with 12 known compounds (2–13). The structure of the new compound was established by 1D and 2D NMR, MS data and circular dichroism analysis. Polyprenylated flavonoids 6–9 and 11–13 increased GLUT-4 translocation by the range of 1.35–2.75 folds. Sophoranone (8) exerted the strongest activity with 2.75 folds GLUT-4 translocation enhancement at the concentration of 10 μM. This is the first report of the GLUT-4 translocation ...
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    Bioassay-guided phytochemical investigation of the EtOAc fraction (ST-EtOAc) from the roots of Sophora tonkinensis resulted in the isolation of a new compound 6aR,11aR-1-hydroxy-4-isoprenyl-maackiain (1), along with 12 known compounds (2–13). The structure of the new compound was established by 1D and 2D NMR, MS data and circular dichroism analysis. Polyprenylated flavonoids 6–9 and 11–13 increased GLUT-4 translocation by the range of 1.35–2.75 folds. Sophoranone (8) exerted the strongest activity with 2.75 folds GLUT-4 translocation enhancement at the concentration of 10 μM. This is the first report of the GLUT-4 translocation activity of the plant Sophora tonkinensis.
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    Journal Title
    Bioorganic & Medicinal Chemistry Letters
    Volume
    27
    Issue
    6
    DOI
    https://doi.org/10.1016/j.bmcl.2017.01.078
    Copyright Statement
    © 2017 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
    Subject
    Medicinal and biomolecular chemistry
    Organic chemistry
    Biochemistry and cell biology not elsewhere classified
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/374214
    Collection
    • Journal articles

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