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dc.contributor.authorCoffeng, Luc E
dc.contributor.authorStolk, Wilma A
dc.contributor.authorZoure, Honorat GM
dc.contributor.authorVeerman, J Lennert
dc.contributor.authorAgblewonu, Koffi B
dc.contributor.authorMurdoch, Michele E
dc.contributor.authorNoma, Mounkaila
dc.contributor.authorFobi, Grace
dc.contributor.authorRichardus, Jan Hendrik
dc.contributor.authorBundy, Donald AP
dc.contributor.authorHabbema, Dik
dc.contributor.authorde Vlas, Sake J
dc.contributor.authorAmazigo, Uche V
dc.date.accessioned2018-05-07T22:27:33Z
dc.date.available2018-05-07T22:27:33Z
dc.date.issued2013
dc.identifier.issn1935-2735
dc.identifier.doi10.1371/journal.pntd.0002032
dc.identifier.urihttp://hdl.handle.net/10072/374318
dc.description.abstractBackground: Onchocerciasis causes a considerable disease burden in Africa, mainly through skin and eye disease. Since 1995, the African Programme for Onchocerciasis Control (APOC) has coordinated annual mass treatment with ivermectin in 16 countries. In this study, we estimate the health impact of APOC and the associated costs from a program perspective up to 2010 and provide expected trends up to 2015. Methods and Findings: With data on pre-control prevalence of infection and population coverage of mass treatment, we simulated trends in infection, blindness, visual impairment, and severe itch using the micro-simulation model ONCHOSIM, and estimated disability-adjusted life years (DALYs) lost due to onchocerciasis. We assessed financial costs for APOC, beneficiary governments, and non-governmental development organizations, excluding cost of donated drugs. We estimated that between 1995 and 2010, mass treatment with ivermectin averted 8.2 million DALYs due to onchocerciasis in APOC areas, at a nominal cost of about US$257 million. We expect that APOC will avert another 9.2 million DALYs between 2011 and 2015, at a nominal cost of US$221 million. Conclusions: Our simulations suggest that APOC has had a remarkable impact on population health in Africa between 1995 and 2010. This health impact is predicted to double during the subsequent five years of the program, through to 2015. APOC is a highly cost-effective public health program. Given the anticipated elimination of onchocerciasis from some APOC areas, we expect even more health gains and a more favorable cost-effectiveness of mass treatment with ivermectin in the near future.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherPublic Library of Science
dc.relation.ispartofpagefrome2032-1
dc.relation.ispartofpagetoe2032-9
dc.relation.ispartofissue6
dc.relation.ispartofjournalPloS Neglected Tropical Diseases
dc.relation.ispartofvolume8
dc.subject.fieldofresearchHealth Economics
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode140208
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.titleAfrican Programme for Onchocerciasis Control 1995-2015: Model-Estimated Health Impact and Cost
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
gro.rights.copyrightCopyright: © 2013 Coffeng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
gro.hasfulltextFull Text
gro.griffith.authorVeerman, Lennert L.


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