dc.contributor.author | Sleeman, Isobel | |
dc.contributor.author | Aspray, Terry | |
dc.contributor.author | Lawson, Rachael | |
dc.contributor.author | Coleman, Shirley | |
dc.contributor.author | Duncan, Gordon | |
dc.contributor.author | Khoo, Tien K | |
dc.contributor.author | Schoenmakers, Inez | |
dc.contributor.author | Rochester, Lynn | |
dc.contributor.author | Burn, David | |
dc.contributor.author | Yarnall, Alison | |
dc.date.accessioned | 2018-05-02T05:18:53Z | |
dc.date.available | 2018-05-02T05:18:53Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1877-7171 | |
dc.identifier.doi | 10.3233/JPD-171122 | |
dc.identifier.uri | http://hdl.handle.net/10072/374345 | |
dc.description.abstract | Background:
Previous cross-sectional studies have shown that Parkinson’s disease (PD) patients have lower serum 25-hydroxy vitamin D (25(OH)D) concentrations than controls. Vitamin D deficiency was associated with increased disease severity and cognitive impairment in prevalent PD patients.
Objective:
The aim of the study was to determine 25(OH)D in newly diagnosed PD and age-matched controls and to assess if there was an association with clinical outcomes (disease severity, cognition and falls) over the 36-month follow up period.
Methods:
A prospective observational study of newly diagnosed PD patients in the North East of England with age-matched controls (PD, n = 145; control, n = 94). Serum 25(OH)D was assessed at baseline and 18 months. Participants underwent clinical assessment at baseline, 18 and 36 months. One hundred and ten participants with PD also took part in a prospective falls study.
Results:
Mean serum 25(OH)D concentrations were lower in PD than control participants at baseline (44.1±21.7 vs. 52.2±22.1 nmol/L, p < 0.05) and 18 months (44.2±23.6 vs. 55.7±28.8 nmol/L, p < 0.05). Baseline serum 25(OH)D concentration, age, motor score and dosage of dopaminergic medication were significant predictors of variance of motor severity at 36 months ((ΔR2 = 0.039, F = 6.6, p < 0.01). Serum 25(OH)D was not associated with cognition or falls during the follow up period.
Conclusions:
Patients with incident PD had significantly lower serum 25(OH)D concentrations than age-matched controls, which may have implications in terms of bone health and fracture risk. There was a small but significant association between vitamin D status at baseline and disease motor severity at 36 months. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | IOS Press | |
dc.relation.ispartofpagefrom | 669 | |
dc.relation.ispartofpageto | 675 | |
dc.relation.ispartofissue | 4 | |
dc.relation.ispartofjournal | Journal of Parkinson's Disease | |
dc.relation.ispartofvolume | 7 | |
dc.subject.fieldofresearch | Neurosciences | |
dc.subject.fieldofresearch | Neurology and neuromuscular diseases | |
dc.subject.fieldofresearchcode | 3209 | |
dc.subject.fieldofresearchcode | 320905 | |
dc.title | The Role of Vitamin D in Disease Progression in Early Parkinson's Disease | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | http://creativecommons.org/licenses/by/4.0/ | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © IOS Press and the authors. This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Khoo, Tien Kheng | |