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  • The role of sleep difficulties in the vasomotor menopausal symptoms and depressed mood relationships: an international pooled analysis of eight studies in the InterLACE consortium

    Author(s)
    Chung, Hsin-Fang
    Pandeya, Nirmala
    Dobson, Annette J
    Kuh, Diana
    Brunner, Eric J
    Crawford, Sybil L
    Avis, Nancy E
    Gold, Ellen B
    Mitchell, Ellen S
    Woods, Nancy F
    Bromberger, Joyce T
    Thurston, Rebecca C
    Joffe, Hadine
    Yoshizawa, Toyoko
    Anderson, Debra
    Mishra, Gita D
    Griffith University Author(s)
    Anderson, Debra J.
    Year published
    2018
    Metadata
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    Abstract
    Background: Many women experience both vasomotor menopausal symptoms (VMS) and depressed mood at midlife, but little is known regarding the prospective bi-directional relationships between VMS and depressed mood and the role of sleep difficulties in both directions. Methods: A pooled analysis was conducted using data from 21 312 women (median: 50 years, interquartile range 49−51) in eight studies from the InterLACE consortium. The degree of VMS, sleep difficulties, and depressed mood was self-reported and categorised as never, rarely, sometimes, and often (if reporting frequency) or never, mild, moderate, and severe (if ...
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    Background: Many women experience both vasomotor menopausal symptoms (VMS) and depressed mood at midlife, but little is known regarding the prospective bi-directional relationships between VMS and depressed mood and the role of sleep difficulties in both directions. Methods: A pooled analysis was conducted using data from 21 312 women (median: 50 years, interquartile range 49−51) in eight studies from the InterLACE consortium. The degree of VMS, sleep difficulties, and depressed mood was self-reported and categorised as never, rarely, sometimes, and often (if reporting frequency) or never, mild, moderate, and severe (if reporting severity). Multivariable logistic regression models were used to examine the bi-directional associations adjusted for within-study correlation. Results: At baseline, the prevalence of VMS (40%, range 13–62%) and depressed mood (26%, 8–41%) varied substantially across studies, and a strong dose-dependent association between VMS and likelihood of depressed mood was found. Over 3 years of follow-up, women with often/severe VMS at baseline were more likely to have subsequent depressed mood compared with those without VMS (odds ratios (OR) 1.56, 1.27–1.92). Women with often/severe depressed mood at baseline were also more likely to have subsequent VMS than those without depressed mood (OR 1.89, 1.47–2.44). With further adjustment for the degree of sleep difficulties at baseline, the OR of having a subsequent depressed mood associated with often/severe VMS was attenuated and no longer significant (OR 1.13, 0.90–1.40). Conversely, often/severe depressed mood remained significantly associated with subsequent VMS (OR 1.80, 1.38–2.34). Conclusions: Difficulty in sleeping largely explained the relationship between VMS and subsequent depressed mood, but it had little impact on the relationship between depressed mood and subsequent VMS.
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    Journal Title
    Psychological Medicine
    DOI
    https://doi.org/10.1017/S0033291718000168
    Note
    This publication has been entered into Griffith Research Online as an Advanced Online Version.
    Subject
    Neurosciences
    Health services and systems
    Public health
    Psychology
    Other psychology not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/374804
    Collection
    • Journal articles

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