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dc.contributor.authorChung, Hsin-Fang
dc.contributor.authorPandeya, Nirmala
dc.contributor.authorDobson, Annette J
dc.contributor.authorKuh, Diana
dc.contributor.authorBrunner, Eric J
dc.contributor.authorCrawford, Sybil L
dc.contributor.authorAvis, Nancy E
dc.contributor.authorGold, Ellen B
dc.contributor.authorMitchell, Ellen S
dc.contributor.authorWoods, Nancy F
dc.contributor.authorBromberger, Joyce T
dc.contributor.authorThurston, Rebecca C
dc.contributor.authorJoffe, Hadine
dc.contributor.authorYoshizawa, Toyoko
dc.contributor.authorAnderson, Debra
dc.contributor.authorMishra, Gita D
dc.date.accessioned2019-07-05T12:31:05Z
dc.date.available2019-07-05T12:31:05Z
dc.date.issued2018
dc.identifier.issn0033-2917
dc.identifier.doi10.1017/S0033291718000168
dc.identifier.urihttp://hdl.handle.net/10072/374804
dc.description.abstractBackground: Many women experience both vasomotor menopausal symptoms (VMS) and depressed mood at midlife, but little is known regarding the prospective bi-directional relationships between VMS and depressed mood and the role of sleep difficulties in both directions. Methods: A pooled analysis was conducted using data from 21 312 women (median: 50 years, interquartile range 49−51) in eight studies from the InterLACE consortium. The degree of VMS, sleep difficulties, and depressed mood was self-reported and categorised as never, rarely, sometimes, and often (if reporting frequency) or never, mild, moderate, and severe (if reporting severity). Multivariable logistic regression models were used to examine the bi-directional associations adjusted for within-study correlation. Results: At baseline, the prevalence of VMS (40%, range 13–62%) and depressed mood (26%, 8–41%) varied substantially across studies, and a strong dose-dependent association between VMS and likelihood of depressed mood was found. Over 3 years of follow-up, women with often/severe VMS at baseline were more likely to have subsequent depressed mood compared with those without VMS (odds ratios (OR) 1.56, 1.27–1.92). Women with often/severe depressed mood at baseline were also more likely to have subsequent VMS than those without depressed mood (OR 1.89, 1.47–2.44). With further adjustment for the degree of sleep difficulties at baseline, the OR of having a subsequent depressed mood associated with often/severe VMS was attenuated and no longer significant (OR 1.13, 0.90–1.40). Conversely, often/severe depressed mood remained significantly associated with subsequent VMS (OR 1.80, 1.38–2.34). Conclusions: Difficulty in sleeping largely explained the relationship between VMS and subsequent depressed mood, but it had little impact on the relationship between depressed mood and subsequent VMS.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherCambridge University Press
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto12
dc.relation.ispartofjournalPsychological Medicine
dc.subject.fieldofresearchPsychology not elsewhere classified
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode170199
dc.subject.fieldofresearchcode1701
dc.subject.fieldofresearchcode1117
dc.subject.fieldofresearchcode1109
dc.titleThe role of sleep difficulties in the vasomotor menopausal symptoms and depressed mood relationships: an international pooled analysis of eight studies in the InterLACE consortium
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.hasfulltextNo Full Text
gro.griffith.authorAnderson, Debra J.


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