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dc.contributor.authorGrice, Darrenen_US
dc.contributor.authorGriffiths, Lynen_US
dc.contributor.authorRogers, Kellyen_US
dc.date.accessioned2017-04-04T15:16:37Z
dc.date.available2017-04-04T15:16:37Z
dc.date.issued2011en_US
dc.date.modified2013-05-29T03:16:09Z
dc.identifier.issn1741427Xen_US
dc.identifier.doi10.1093/ecam/nep213en_US
dc.identifier.urihttp://hdl.handle.net/10072/37491
dc.description.abstractInfusions and decoctions of Cymbopogon ambiguus have been used traditionally in Australia for the treatment of headache, chest infections and muscle cramps. The aim of the present study was to screen and identify bioactive compounds from C. ambiguus that could explain this plant's anti-headache activity. A dichloromethane extract of C. ambiguus was identified as having activity in adenosine-diphosphate-induced human platelet aggregation and serotonin-release inhibition bioassays. Subsequent fractionation of this extract led to the isolation of four phenylpropenoids, eugenol, elemicin, eugenol methylether and trans-isoelemicin. While both eugenol and elemicin exhibited dose-dependent inhibition of ADP-induced human platelet serotonin release, only eugenol displayed potent inhibitory activity with an IC50 value of 46.6 mM, in comparison to aspirin, with an IC50 value of 46.1 mM. These findings provide evidence to support the therapeutic efficacy of C. ambiguus in the non-conventional treatment of headache and inflammatory conditions.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent280747 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherHindawi Publishing Corporationen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto8en_US
dc.relation.ispartofjournalEvidence-Based Complementary and Alternative Medicineen_US
dc.relation.ispartofvolume2011en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchComplementary and Alternative Medicine not elsewhere classifieden_US
dc.subject.fieldofresearchcode110499en_US
dc.titleIsolation of bioactive compounds that relate to the anti-platelet activity of Cymbopogon ambiguusen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomicsen_US
gro.rights.copyrightCopyright 2010 Oxford University Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_US
gro.date.issued2011
gro.hasfulltextFull Text


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    Contains articles published by Griffith authors in scholarly journals.

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