Diagnostic accuracy of early magnetic resonance imaging to determine motor outcomes in infants born preterm: A systematic review and meta-analysis
Author(s)
George, Joanne M
Pannek, Kerstin
Rose, Stephen E
Ware, Robert S
Colditz, Paul B
Boyd, Roslyn N
Year published
2018
Metadata
Show full item recordAbstract
Aim:
To examine the diagnostic ability of early magnetic resonance imaging (MRI; <36wks postmenstrual age) to detect later adverse motor outcomes or cerebral palsy (CP) in infants born preterm.
Method:
Studies of infants born preterm with MRI earlier than 36 weeks postmenstrual age and quantitative motor data or a diagnosis of CP at or beyond 1 year corrected age were identified. Study details were extracted and meta‐analyses performed where possible. Quality of included studies was evaluated with the QUADAS‐2 (a revised tool for the quality assessment of diagnostic accuracy studies).
Results:
Thirty‐one articles met the ...
View more >Aim: To examine the diagnostic ability of early magnetic resonance imaging (MRI; <36wks postmenstrual age) to detect later adverse motor outcomes or cerebral palsy (CP) in infants born preterm. Method: Studies of infants born preterm with MRI earlier than 36 weeks postmenstrual age and quantitative motor data or a diagnosis of CP at or beyond 1 year corrected age were identified. Study details were extracted and meta‐analyses performed where possible. Quality of included studies was evaluated with the QUADAS‐2 (a revised tool for the quality assessment of diagnostic accuracy studies). Results: Thirty‐one articles met the inclusion criteria, five of which reported diagnostic accuracy and five reported data sufficient for calculation of diagnostic accuracy. Early structural MRI global scores detected a later diagnosis of CP with a pooled sensitivity of 100% (95% confidence interval [CI] 86–100) and a specificity of 93% (95% CI 59–100). Global structural MRI scores determined adverse motor outcomes with a pooled sensitivity of 89% (95% CI 44–100) and a specificity of 98% (95% CI 90–100). White matter scores determined adverse motor outcomes with a pooled sensitivity of 33% (95% CI 20–48) and a specificity of 83% (95% CI 78–88). Interpretation: Early structural MRI has reasonable sensitivity and specificity to determine adverse motor outcomes and CP in infants born preterm. Greater reporting of diagnostic accuracy in studies examining relationships with motor outcomes and CP is required to facilitate clinical utility of early MRI.
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View more >Aim: To examine the diagnostic ability of early magnetic resonance imaging (MRI; <36wks postmenstrual age) to detect later adverse motor outcomes or cerebral palsy (CP) in infants born preterm. Method: Studies of infants born preterm with MRI earlier than 36 weeks postmenstrual age and quantitative motor data or a diagnosis of CP at or beyond 1 year corrected age were identified. Study details were extracted and meta‐analyses performed where possible. Quality of included studies was evaluated with the QUADAS‐2 (a revised tool for the quality assessment of diagnostic accuracy studies). Results: Thirty‐one articles met the inclusion criteria, five of which reported diagnostic accuracy and five reported data sufficient for calculation of diagnostic accuracy. Early structural MRI global scores detected a later diagnosis of CP with a pooled sensitivity of 100% (95% confidence interval [CI] 86–100) and a specificity of 93% (95% CI 59–100). Global structural MRI scores determined adverse motor outcomes with a pooled sensitivity of 89% (95% CI 44–100) and a specificity of 98% (95% CI 90–100). White matter scores determined adverse motor outcomes with a pooled sensitivity of 33% (95% CI 20–48) and a specificity of 83% (95% CI 78–88). Interpretation: Early structural MRI has reasonable sensitivity and specificity to determine adverse motor outcomes and CP in infants born preterm. Greater reporting of diagnostic accuracy in studies examining relationships with motor outcomes and CP is required to facilitate clinical utility of early MRI.
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Journal Title
Developmental Medicine and Child Neurology
Volume
60
Issue
2
Subject
Neurology and Neuromuscular Diseases
Medical and Health Sciences