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dc.contributor.authorKorolik, Victoriaen_US
dc.date.accessioned2017-05-03T11:42:32Z
dc.date.available2017-05-03T11:42:32Z
dc.date.issued2010en_US
dc.date.modified2011-10-06T05:00:53Z
dc.identifier.issn2150-5594en_US
dc.identifier.doi10.4161/viru.1.5.12735en_AU
dc.identifier.urihttp://hdl.handle.net/10072/37549
dc.description.abstractThe human bacterial pathogen Campylobacter jejuni is able to respond to environmental stimuli utilising chemotactic motility. The bacterial senses external molecules via transmembrane sensory proteins called Transducer Like Proteins, TLPs. The specificity of the Tlp1 chemoreceptor (Cj1506c) of C. jejuni as the aspartate receptor, CcaA, and its role in chemotaxis signalling pathway were characterised by genetic and biochemical approaches including amino acid and small molecule arrays, Saturation Transfer Difference NMR spectroscopy, and mutational analysis. Yeast two-hybrid and three-hybrid analysis of protein-protein interactions showed that CcaA chemotactic signal was preferentially passed through CheV, rather than the CheW homologue of the chemotaxis signalling pathway allowing a new model for the C. jejuni chemotactic signalling pathway to be postulated.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent136004 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherLandes Bioscienceen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom417en_US
dc.relation.ispartofpageto420en_US
dc.relation.ispartofissue5en_US
dc.relation.ispartofjournalVirulenceen_US
dc.relation.ispartofvolume1en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchInfectious Agentsen_US
dc.subject.fieldofresearchcode060502en_US
dc.titleAspartate chemosensory receptor signalling in Campylobacter jejunien_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.rights.copyrightCopyright remains with the author 2010. This is the author-manuscript version of this paper. It is posted here with permission of the copyright owner for your personal use only. No further distribution permitted. For information about this journal please refer to the journal's website or contact the author.en_AU
gro.date.issued2010
gro.hasfulltextFull Text


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