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  • MicroRNA 183 family profiles in pheochromocytomas are related to clinical parameters and SDHB expression

    Author(s)
    Pillai, Suja
    Lo, Chung Y
    Liew, Victor
    Lalloz, Minella
    Smith, Robert A
    Gopalan, Vinod
    Lam, Alfred King-Yin
    Griffith University Author(s)
    Smith, Robert A.
    Lam, Alfred K.
    Gopalan, Vinod
    Pillai, Suja
    Lalloz, Minella
    Year published
    2017
    Metadata
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    Abstract
    This study aims to examine the expression profiles of the miR-183 cluster (miR-96/182/183) in pheochromocytoma. Pheochromocytoma tissues were prospectively collected from 50 patients with pheochromocytoma. Expression of miR-183 cluster members and SDHB protein expression were analyzed in these tissues by quantitative real-time polymerase chain reaction and immunohistochemistry, respectively. The expression of miR-183 cluster members in pheochromocytomas was correlated with the clinical and pathological parameters of these patients. The expression levels of miR-183 cluster members were predominantly downregulated or deleted ...
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    This study aims to examine the expression profiles of the miR-183 cluster (miR-96/182/183) in pheochromocytoma. Pheochromocytoma tissues were prospectively collected from 50 patients with pheochromocytoma. Expression of miR-183 cluster members and SDHB protein expression were analyzed in these tissues by quantitative real-time polymerase chain reaction and immunohistochemistry, respectively. The expression of miR-183 cluster members in pheochromocytomas was correlated with the clinical and pathological parameters of these patients. The expression levels of miR-183 cluster members were predominantly downregulated or deleted in pheochromocytoma. Low expression or deletion of miR-96 was predominantly noted in younger patients with pheochromocytoma (<50 years, P = .01). Female patients in the study group showed marked deletion of miR-182 (P = .05). Deletion of the cluster was also associated with SDHB protein expression in pheochromocytoma. Moreover, patients with low miR-183 cluster expression had a slightly better survival rate when compared with patients with high expression. To conclude, the findings indicate a role for miR-183 cluster members in the pathogenesis and clinical progression of pheochromocytoma.
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    Journal Title
    Human Pathology
    Volume
    64
    DOI
    https://doi.org/10.1016/j.humpath.2017.03.017
    Subject
    Clinical sciences
    Pathology (excl. oral pathology)
    Publication URI
    http://hdl.handle.net/10072/375669
    Collection
    • Journal articles

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