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dc.contributor.authorPillai, Suja
dc.contributor.authorLo, Chung Y
dc.contributor.authorLiew, Victor
dc.contributor.authorLalloz, Minella
dc.contributor.authorSmith, Robert A
dc.contributor.authorGopalan, Vinod
dc.contributor.authorLam, Alfred King-Yin
dc.date.accessioned2018-05-22T00:05:45Z
dc.date.available2018-05-22T00:05:45Z
dc.date.issued2017
dc.identifier.issn0046-8177
dc.identifier.doi10.1016/j.humpath.2017.03.017
dc.identifier.urihttp://hdl.handle.net/10072/375669
dc.description.abstractThis study aims to examine the expression profiles of the miR-183 cluster (miR-96/182/183) in pheochromocytoma. Pheochromocytoma tissues were prospectively collected from 50 patients with pheochromocytoma. Expression of miR-183 cluster members and SDHB protein expression were analyzed in these tissues by quantitative real-time polymerase chain reaction and immunohistochemistry, respectively. The expression of miR-183 cluster members in pheochromocytomas was correlated with the clinical and pathological parameters of these patients. The expression levels of miR-183 cluster members were predominantly downregulated or deleted in pheochromocytoma. Low expression or deletion of miR-96 was predominantly noted in younger patients with pheochromocytoma (<50 years, P = .01). Female patients in the study group showed marked deletion of miR-182 (P = .05). Deletion of the cluster was also associated with SDHB protein expression in pheochromocytoma. Moreover, patients with low miR-183 cluster expression had a slightly better survival rate when compared with patients with high expression. To conclude, the findings indicate a role for miR-183 cluster members in the pathogenesis and clinical progression of pheochromocytoma.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier
dc.relation.ispartofpagefrom91
dc.relation.ispartofpageto97
dc.relation.ispartofjournalHuman Pathology
dc.relation.ispartofvolume64
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchPathology (excl. oral pathology)
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode320220
dc.titleMicroRNA 183 family profiles in pheochromocytomas are related to clinical parameters and SDHB expression
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medicine
gro.hasfulltextNo Full Text
gro.griffith.authorSmith, Robert A.
gro.griffith.authorLam, Alfred K.
gro.griffith.authorGopalan, Vinod
gro.griffith.authorPillai, Suja
gro.griffith.authorLalloz, Minella


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