Investigating the Effects of Statins in Neuroinflammation-induced Neurodegeneration
Author(s)
Primary Supervisor
Anoopkumar-Dukie, Shailendra
Other Supervisors
Lewohl, Joanne
Grant, Gary
McDermott, Catherine
Davey, Andrew
Year published
2017-11
Metadata
Show full item recordAbstract
Statins are widely used in primary and secondary prevention of atherosclerotic cardiovascular disease. Despite being generally considered as safe for use, current clinical evidence regarding the neurological effects of statins is conflicting. Although a number of large-scale studies suggest that statins are largely neuroprotective, case reports suggest a possible association between statins and adverse cognitive effects in the form of cognitive decline or memory impairment. There are numerous limitations surrounding existing in vitro and in vivo studies investigating statins' central nervous system (CNS) effects, including ...
View more >Statins are widely used in primary and secondary prevention of atherosclerotic cardiovascular disease. Despite being generally considered as safe for use, current clinical evidence regarding the neurological effects of statins is conflicting. Although a number of large-scale studies suggest that statins are largely neuroprotective, case reports suggest a possible association between statins and adverse cognitive effects in the form of cognitive decline or memory impairment. There are numerous limitations surrounding existing in vitro and in vivo studies investigating statins' central nervous system (CNS) effects, including a lack of comparison between the different statin compounds. Consequently, a thorough understanding of statins' mechanistic effects within the CNS has not been possible to date. The overall aim of this project was to determine the mechanisms underlying the effects of multiple structurally and pharmacologically diverse statins in neuroinflammation and subsequent neurodegeneration. This was achieved through a combination of in vitro and in vivo studies. [...]
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View more >Statins are widely used in primary and secondary prevention of atherosclerotic cardiovascular disease. Despite being generally considered as safe for use, current clinical evidence regarding the neurological effects of statins is conflicting. Although a number of large-scale studies suggest that statins are largely neuroprotective, case reports suggest a possible association between statins and adverse cognitive effects in the form of cognitive decline or memory impairment. There are numerous limitations surrounding existing in vitro and in vivo studies investigating statins' central nervous system (CNS) effects, including a lack of comparison between the different statin compounds. Consequently, a thorough understanding of statins' mechanistic effects within the CNS has not been possible to date. The overall aim of this project was to determine the mechanisms underlying the effects of multiple structurally and pharmacologically diverse statins in neuroinflammation and subsequent neurodegeneration. This was achieved through a combination of in vitro and in vivo studies. [...]
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Thesis Type
Thesis (PhD Doctorate)
Degree Program
Doctor of Philosophy (PhD)
School
School of Pharmacy and Pharmac
Copyright Statement
The author owns the copyright in this thesis, unless stated otherwise.
Subject
Statins
Neuroinflammation
Neurodegeneration
Atorvastatin
Pravastatin
Rosuvastatin
Simvastatin