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dc.contributor.authorC. Moore, Hannahen_US
dc.contributor.authorJacoby, Peteren_US
dc.contributor.authorTaylor, Amandaen_US
dc.contributor.authorHarnett, Gerryen_US
dc.contributor.authorBowman, Jacintaen_US
dc.contributor.authorRiley, Thomas V.en_US
dc.contributor.authorReuter, Kellyen_US
dc.contributor.authorW. Smith, Daviden_US
dc.contributor.authorLehmann, Deborahen_US
dc.contributor.authorAalberse, J.en_US
dc.contributor.authorAlpers, K.en_US
dc.contributor.authorArumugaswamy, A.en_US
dc.contributor.authorBeissbarth, J.en_US
dc.contributor.authorBonney, P.en_US
dc.contributor.authorBonney, R.en_US
dc.contributor.authorBrestovac, B.en_US
dc.contributor.authorCarter, J.en_US
dc.contributor.authorCarville, K.en_US
dc.contributor.authorCoates, H.en_US
dc.contributor.authorColeman, S.en_US
dc.contributor.authorCripps, Allanen_US
dc.contributor.authorDorizzi, L.en_US
dc.contributor.authorDunn, D.en_US
dc.contributor.authorElsbury, D.en_US
dc.contributor.authorEdwards, E.en_US
dc.contributor.authorEvans, J.en_US
dc.contributor.authorFinucane, J.en_US
dc.contributor.authorFirth, M.en_US
dc.contributor.authorForrest, A.en_US
dc.contributor.authoral, eten_US
dc.date.accessioned2017-04-24T11:47:47Z
dc.date.available2017-04-24T11:47:47Z
dc.date.issued2010en_US
dc.identifier.issn08913668en_US
dc.identifier.urihttp://hdl.handle.net/10072/37590
dc.description.abstractBackground: Associations between respiratory viruses and the bacterial pathogens Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis may be important in the pathogenesis of otitis media (OM). However, data on asymptomatic identification rates of respiratory viruses are limited, particularly in Indigenous populations, who suffer a high burden of OM. Methods: We describe the identification of respiratory viruses alone and in combination with pathogenic OM bacteria in 1006 nasopharyngeal aspirates collected from asymptomatic Aboriginal and non-Aboriginal children in a longitudinal community-based cohort study in rural Western Australia. Results: Viruses were identified in 42% of samples from Aboriginal and 32% from non-Aboriginal children. Rhinoviruses were the most frequently identified virus with higher identification rates in Aboriginal (23.6%) than non-Aboriginal children (16.5%; P = 0.003). Rhinoviruses were associated with H. influenzae (odds ratio [OR], 2.24; 95% CI, 1.24-4.07 for Aboriginal children) and M. catarrhalis (OR, 1.94; 95% CI, 1.05-3.57 for Aboriginal children). Adenoviruses were positively associated with H. influenzae in Aboriginal children (OR, 3.30; 95% CI, 1.19-9.09) and M. catarrhalis in non-Aboriginal children (OR, 5.75; 95% CI, 1.74-19.23), but negatively associated with S. pneumoniae in Aboriginal children (OR, 0.39; 95% CI, 0.18-0.84). Conclusions: We found a high identification rate of rhinoviruses and adenoviruses in asymptomatic children. The associations between these viruses and OM bacteria have implications for preventive strategies targeted at specific pathogens.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent154142 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.publisher.placeUnited Statesen_US
dc.publisher.urihttp://journals.lww.com/pidj/Abstract/2010/06000/The_Interaction_Between_Respiratory_Viruses_and.14.aspxen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom540en_US
dc.relation.ispartofpageto545en_US
dc.relation.ispartofissue6en_US
dc.relation.ispartofjournalPediatric Infectious Disease Journalen_US
dc.relation.ispartofvolume29en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchImmunology not elsewhere classifieden_US
dc.subject.fieldofresearchcode110799en_US
dc.titleThe interaction between respiratory viruses and pathogenic bacteria in the upper respiratory tract of asymptomatic Aboriginal and non-Aboriginal childrenen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2010 Lippincott Williams & Wilkins. This is a non-final version of an article published in final form in the Pediatric Infectious Disease Journal, Vol. 29(6), pp. 540-545. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal link for access to the definitive, published version.en_US
gro.date.issued2014-10-10T01:56:03Z
gro.hasfulltextFull Text


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