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  • Enteroendocrine and adipokine associations with type 2 diabetes: Phenotypic risk scoring approaches

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    CoxPUB5067.pdf (614.0Kb)
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    Accepted Manuscript (AM)
    Author(s)
    Cox, Amanda J
    Zhang, Ping
    Bowden, Donald W
    Devereaux, Benedict
    Davoren, Peter M
    Cripps, Allan W
    West, Nicholas P
    Griffith University Author(s)
    Cripps, Allan W.
    West, Nic P.
    Davoren, Peter M.
    Cox, Amanda J.
    Zhang, Ping
    Year published
    2018
    Metadata
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    Abstract
    Background and Aim: The contribution of gut‐derived factors to the mechanisms linking obesity and metabolic disease remains under‐investigated. The aim of the current study was to examine the associations between glucagon and enteroendocrine signaling and type 2 diabetes (T2D) using a derived risk score approach. To compare the relative importance of the enteroendocrine system, associations between adipokine measures and T2D were also investigated. Methods: A total of 130 individuals with T2D and 161 individuals without T2D were included in the study. Circulating concentrations of enteroendocrine (glucagon, ghrelin, ...
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    Background and Aim: The contribution of gut‐derived factors to the mechanisms linking obesity and metabolic disease remains under‐investigated. The aim of the current study was to examine the associations between glucagon and enteroendocrine signaling and type 2 diabetes (T2D) using a derived risk score approach. To compare the relative importance of the enteroendocrine system, associations between adipokine measures and T2D were also investigated. Methods: A total of 130 individuals with T2D and 161 individuals without T2D were included in the study. Circulating concentrations of enteroendocrine (glucagon, ghrelin, glucagon‐like peptide‐1, and gastric inhibitory peptide) and adipokine mediators (adiponectin, leptin, resistin, visfatin, and adipsin) were measured. Standard scores (Z‐scores) were determined for each measure and enteroendocrine risk scores (ERS) and adipokine risk scores (ARS) calculated based on summation of the component measures. Associations between both the ERS and ARS and T2D status were assessed using logistic regression models. Results: The ERS was significantly associated with T2D status in an adjusted model (odds ratio: 1.36; 95% confidence interval [CI]: 1.08–1.72; P = 0.009). Associations between the ARS and T2D status were not independent of age, sex, and body mass index (odds ratio: 1.21; 95%CI: 0.99–1.47; P = 0.06). Quantification of risk across ERS tertiles revealed that individuals with an ERS in the upper tertile were 10 times more likely (CI: 3.23–32.73; P < 0.001) to have T2D. Conclusions: These data support an association between enteroendocrine signaling and T2D. Use of the ERS as a potential tool for classifying individuals with metabolic syndrome as high or low risk for T2D development is being considered.
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    Journal Title
    Journal of Gastroenterology and Hepatology
    Volume
    33
    Issue
    7
    DOI
    https://doi.org/10.1111/jgh.14057
    Copyright Statement
    © 2018 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd. This is the peer reviewed version of the following article: Enteroendocrine and adipokine associations with type 2 diabetes: Phenotypic risk scoring approaches, Journal of Gastroenterology and Hepatology, Volume 33, Issue 7, July 2018, Pages 1357-1364, which has been published in final form at 10.1111/jgh.14057. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
    Note
    This publication has been entered into Griffith Research Online as an Advanced Online Version.
    Subject
    Clinical sciences
    Clinical sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/376100
    Collection
    • Journal articles

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