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dc.contributor.authorCox, Amanda J
dc.contributor.authorZhang, Ping
dc.contributor.authorBowden, Donald W
dc.contributor.authorDevereaux, Benedict
dc.contributor.authorDavoren, Peter M
dc.contributor.authorCripps, Allan W
dc.contributor.authorWest, Nicholas P
dc.date.accessioned2019-06-07T01:31:10Z
dc.date.available2019-06-07T01:31:10Z
dc.date.issued2018
dc.identifier.issn0815-9319
dc.identifier.doi10.1111/jgh.14057
dc.identifier.urihttp://hdl.handle.net/10072/376100
dc.description.abstractBackground and Aim: The contribution of gut‐derived factors to the mechanisms linking obesity and metabolic disease remains under‐investigated. The aim of the current study was to examine the associations between glucagon and enteroendocrine signaling and type 2 diabetes (T2D) using a derived risk score approach. To compare the relative importance of the enteroendocrine system, associations between adipokine measures and T2D were also investigated. Methods: A total of 130 individuals with T2D and 161 individuals without T2D were included in the study. Circulating concentrations of enteroendocrine (glucagon, ghrelin, glucagon‐like peptide‐1, and gastric inhibitory peptide) and adipokine mediators (adiponectin, leptin, resistin, visfatin, and adipsin) were measured. Standard scores (Z‐scores) were determined for each measure and enteroendocrine risk scores (ERS) and adipokine risk scores (ARS) calculated based on summation of the component measures. Associations between both the ERS and ARS and T2D status were assessed using logistic regression models. Results: The ERS was significantly associated with T2D status in an adjusted model (odds ratio: 1.36; 95% confidence interval [CI]: 1.08–1.72; P = 0.009). Associations between the ARS and T2D status were not independent of age, sex, and body mass index (odds ratio: 1.21; 95%CI: 0.99–1.47; P = 0.06). Quantification of risk across ERS tertiles revealed that individuals with an ERS in the upper tertile were 10 times more likely (CI: 3.23–32.73; P < 0.001) to have T2D. Conclusions: These data support an association between enteroendocrine signaling and T2D. Use of the ERS as a potential tool for classifying individuals with metabolic syndrome as high or low risk for T2D development is being considered.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing
dc.publisher.placeAustralia
dc.relation.ispartofpagefrom1357
dc.relation.ispartofpageto1364
dc.relation.ispartofissue7
dc.relation.ispartofjournalJournal of Gastroenterology and Hepatology
dc.relation.ispartofvolume33
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchClinical sciences not elsewhere classified
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode320299
dc.titleEnteroendocrine and adipokine associations with type 2 diabetes: Phenotypic risk scoring approaches
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.facultyGriffith Health, School of Medical Science
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.rights.copyright© 2018 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd. This is the peer reviewed version of the following article: Enteroendocrine and adipokine associations with type 2 diabetes: Phenotypic risk scoring approaches, Journal of Gastroenterology and Hepatology, Volume 33, Issue 7, July 2018, Pages 1357-1364, which has been published in final form at 10.1111/jgh.14057. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
gro.hasfulltextFull Text
gro.griffith.authorCripps, Allan W.
gro.griffith.authorWest, Nic P.
gro.griffith.authorCox, Amanda J.
gro.griffith.authorZhang, Ping


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