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  • Olfactory ensheathing cells from the nose: clinical application in human spinal cord injuries

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    Author(s)
    Mackay-Sim, Alan
    St John, James A
    Griffith University Author(s)
    Mackay-Sim, Alan
    St John, James A.
    Ekberg, Jenny A.
    Year published
    2011
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    Abstract
    Olfactory mucosa, the sense organ of smell, is an adult tissue that is regenerated and repaired throughout life to maintain the integrity of the sense of smell. When the sensory neurons of the olfactory epithelium die they are replaced by proliferation of stem cells and their axons grow from the nose to brain assisted by olfactory ensheathing cells located in the lamina propria beneath the sensory epithelium. When transplanted into the site of traumatic spinal cord injury in rat, olfactory lamina propria or purified olfactory ensheathing cells promote behavioural recovery and assist regrowth of some nerves in the spinal cord. ...
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    Olfactory mucosa, the sense organ of smell, is an adult tissue that is regenerated and repaired throughout life to maintain the integrity of the sense of smell. When the sensory neurons of the olfactory epithelium die they are replaced by proliferation of stem cells and their axons grow from the nose to brain assisted by olfactory ensheathing cells located in the lamina propria beneath the sensory epithelium. When transplanted into the site of traumatic spinal cord injury in rat, olfactory lamina propria or purified olfactory ensheathing cells promote behavioural recovery and assist regrowth of some nerves in the spinal cord. A Phase I clinical trial demonstrated that autologous olfactory ensheathing cell transplantation is safe, with no adverse outcomes recorded for three years following transplantation. Autologous olfactory mucosa transplantation is also being investigated in traumatic spinal cord injury although this whole tissue contains many cells in addition to olfactory ensheathing cells, including stem cells. If olfactory ensheathing cells are proven therapeutic for human spinal cord injury there are several important practical issues that will need to be solved before they reach general clinical application.
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    Journal Title
    Experimental Neurology
    Volume
    229
    Issue
    1
    DOI
    https://doi.org/10.1016/j.expneurol.2010.08.025
    Subject
    Clinical sciences
    Neurosciences
    Central nervous system
    Peripheral nervous system
    Publication URI
    http://hdl.handle.net/10072/37611
    Collection
    • Journal articles

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