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dc.contributor.authorMackay-Sim, Alan
dc.contributor.authorSt John, James A
dc.date.accessioned2017-05-03T15:26:52Z
dc.date.available2017-05-03T15:26:52Z
dc.date.issued2011
dc.date.modified2013-05-29T08:33:21Z
dc.identifier.issn0014-4886
dc.identifier.doi10.1016/j.expneurol.2010.08.025
dc.identifier.urihttp://hdl.handle.net/10072/37611
dc.description.abstractOlfactory mucosa, the sense organ of smell, is an adult tissue that is regenerated and repaired throughout life to maintain the integrity of the sense of smell. When the sensory neurons of the olfactory epithelium die they are replaced by proliferation of stem cells and their axons grow from the nose to brain assisted by olfactory ensheathing cells located in the lamina propria beneath the sensory epithelium. When transplanted into the site of traumatic spinal cord injury in rat, olfactory lamina propria or purified olfactory ensheathing cells promote behavioural recovery and assist regrowth of some nerves in the spinal cord. A Phase I clinical trial demonstrated that autologous olfactory ensheathing cell transplantation is safe, with no adverse outcomes recorded for three years following transplantation. Autologous olfactory mucosa transplantation is also being investigated in traumatic spinal cord injury although this whole tissue contains many cells in addition to olfactory ensheathing cells, including stem cells. If olfactory ensheathing cells are proven therapeutic for human spinal cord injury there are several important practical issues that will need to be solved before they reach general clinical application.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent161201 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherAcademic Press
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom174
dc.relation.ispartofpageto180
dc.relation.ispartofissue1
dc.relation.ispartofjournalExperimental Neurology
dc.relation.ispartofvolume229
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCentral nervous system
dc.subject.fieldofresearchPeripheral nervous system
dc.subject.fieldofresearchBiological psychology
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode320903
dc.subject.fieldofresearchcode320906
dc.subject.fieldofresearchcode5202
dc.titleOlfactory ensheathing cells from the nose: clinical application in human spinal cord injuries
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2011
gro.hasfulltextFull Text
gro.griffith.authorMackay-Sim, Alan
gro.griffith.authorSt John, James A.
gro.griffith.authorEkberg, Jenny A.


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