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dc.contributor.authorCarroll, Anthony R
dc.contributor.authorDuffy, Sandra
dc.contributor.authorAvery, Vicky M
dc.date.accessioned2017-05-03T13:18:03Z
dc.date.available2017-05-03T13:18:03Z
dc.date.issued2010
dc.date.modified2011-04-11T06:49:05Z
dc.identifier.issn0022-3263
dc.identifier.doi10.1021/jo101695v
dc.identifier.urihttp://hdl.handle.net/10072/37657
dc.description.abstractA polyaromatic alkaloid, aplidiopsamine A was isolated from the temperate Australian ascidian, Aplidiopsis confluata, and its structure was determined from interpretation of mass, 1D and 2D NMR spectra. Aplidiopsamine A is the first alkaloid to possess the tricyclic aromatic substructure 3H-pyrrolo[2,3-c]quinoline conjugated to an adenine. Aplidiopsamine A exhibited significant inhibition of growth of chloroquine resistant and sensitive strains of the malaria parasite, Plasmodium falciparum, and minimal toxicity toward human cells.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherAmerican Chemical Society
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom8291
dc.relation.ispartofpageto8294
dc.relation.ispartofissue23
dc.relation.ispartofjournalThe Journal of Organic Chemistry
dc.relation.ispartofvolume75
dc.rights.retentionY
dc.subject.fieldofresearchNatural Products Chemistry
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchOrganic Chemistry
dc.subject.fieldofresearchcode030502
dc.subject.fieldofresearchcode0304
dc.subject.fieldofresearchcode0305
dc.titleAplidiopsamine A, an Antiplasmodial Alkaloid from the Temperate Australian Ascidian, Aplidiopsis confluata
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorCarroll, Anthony R.
gro.griffith.authorDuffy, Sandra
gro.griffith.authorAvery, Vicky M.


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