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  • Oral supplementation with bovine whey-derived Ig-rich fraction and lactoferrin improves SCORAD and DLQI in atopic dermatitis

    Author(s)
    Tong, Philip L
    West, Nicholas P
    Cox, Amanda J
    Gebski, Val J
    Watts, Annabelle M
    Dodds, Annabel
    Fazekas de St Groth, Barbara
    Cripps, Allan W
    Shumack, Stephen
    Griffith University Author(s)
    Cripps, Allan W.
    West, Nic P.
    Cox, Amanda J.
    Year published
    2017
    Metadata
    Show full item record
    Abstract
    Atopic dermatitis (AD) is a chronic but relapsing skin condition, which has a substantial impact on quality of life [1]. Concerns regarding side effects of medications have led to interest in non-pharmacological interventions [2]. While the cellular and molecular mechanisms of AD continue to be elucidated, the immune – skin microbiota aberrations associated with AD [3] are progressively being utilised as a basis for novel treatments for this inflammatory disease. Bovine-derived immune proteins with immunomodulatory properties, such as lactoferrin and the Ig-rich fraction from whey [4], are being investigated for their ...
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    Atopic dermatitis (AD) is a chronic but relapsing skin condition, which has a substantial impact on quality of life [1]. Concerns regarding side effects of medications have led to interest in non-pharmacological interventions [2]. While the cellular and molecular mechanisms of AD continue to be elucidated, the immune – skin microbiota aberrations associated with AD [3] are progressively being utilised as a basis for novel treatments for this inflammatory disease. Bovine-derived immune proteins with immunomodulatory properties, such as lactoferrin and the Ig-rich fraction from whey [4], are being investigated for their effectiveness in AD. Immunoglobulins are key effector molecules produced by plasma cells as part of the adaptive immune response. Lactoferrin is a constitutive component of mucosal secretions and limits bacterial colonisation through iron scavenging. More recently, evidence of a role for lactoferrin in limiting chronic inflammation by linking innate and adaptive immune processes [5] suggests that there may be promise in the use of bovine whey-derived immune proteins in chronic inflammatory diseases
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    Journal Title
    Journal of Dermatological Science
    Volume
    85
    DOI
    https://doi.org/10.1016/j.jdermsci.2016.11.009
    Subject
    Clinical sciences
    Clinical sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/376725
    Collection
    • Journal articles

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