Harnessing the Properties of Natural Products
Author(s)
Boufridi, Asmaa
Quinn, Ronald J
Griffith University Author(s)
Year published
2018
Metadata
Show full item recordAbstract
Natural products (NPs) have been used as traditional medicines since antiquity. With more than 1060 estimated compounds with molecular weights less than 500 Da representing chemical space, NPs occupy a very small percentage; however, they are significantly overrepresented in biologically relevant chemical space. The classical approach concentrates on identifying one or more NPs with biological activity from a source organism. There is much more to be learned from NPs than we can discover this narrow view. In this review, we discuss ways to harness the global properties of NPs.Natural products (NPs) have been used as traditional medicines since antiquity. With more than 1060 estimated compounds with molecular weights less than 500 Da representing chemical space, NPs occupy a very small percentage; however, they are significantly overrepresented in biologically relevant chemical space. The classical approach concentrates on identifying one or more NPs with biological activity from a source organism. There is much more to be learned from NPs than we can discover this narrow view. In this review, we discuss ways to harness the global properties of NPs.
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Journal Title
Annual Review of Pharmacology and Toxicology
Volume
58
Subject
Biological sciences
Biomedical and clinical sciences
Pharmacology and pharmaceutical sciences not elsewhere classified
Pharmacology and pharmaceutical sciences