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  • Immune promotion of epithelial-mesenchymal transition and generation of breast cancer stem cells

    Author(s)
    M. Reiman, Jennifer
    Knutson, Keith
    Radisky, Derek
    Griffith University Author(s)
    Reiman, Jennifer M.
    Year published
    2010
    Metadata
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    Abstract
    Elements of the immune system act as intimate regulators of cancer progression, inhibiting early stages of tumor growth, through immunosurveillance while facilitating later stages of tumor progression. Recent findings have revealed that activated CD8 T cells can stimulate mammary epithelial tumor cells to undergo epithelial-mesenchymal transition (EMT) and to acquire the greatly increased tumorigenic capability and chemotherapeutic resistance of breast cancer stem cells (BCSC). These studies provide a window to understanding how BCSC arise and are maintained within tumors, and how to best target these processes for therapeutic ...
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    Elements of the immune system act as intimate regulators of cancer progression, inhibiting early stages of tumor growth, through immunosurveillance while facilitating later stages of tumor progression. Recent findings have revealed that activated CD8 T cells can stimulate mammary epithelial tumor cells to undergo epithelial-mesenchymal transition (EMT) and to acquire the greatly increased tumorigenic capability and chemotherapeutic resistance of breast cancer stem cells (BCSC). These studies provide a window to understanding how BCSC arise and are maintained within tumors, and how to best target these processes for therapeutic benefit.
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    Journal Title
    Cancer Research
    Volume
    70
    Issue
    8
    DOI
    https://doi.org/10.1158/0008-5472.CAN-09-4041
    Subject
    Tumour Immunology
    Oncology and Carcinogenesis
    Publication URI
    http://hdl.handle.net/10072/37678
    Collection
    • Journal articles

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