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dc.contributor.authorM. Reiman, Jennifer
dc.contributor.authorKnutson, Keith
dc.contributor.authorRadisky, Derek
dc.date.accessioned2017-05-03T15:57:22Z
dc.date.available2017-05-03T15:57:22Z
dc.date.issued2010
dc.date.modified2011-03-23T05:48:02Z
dc.identifier.issn15387445
dc.identifier.doi10.1158/0008-5472.CAN-09-4041
dc.identifier.urihttp://hdl.handle.net/10072/37678
dc.description.abstractElements of the immune system act as intimate regulators of cancer progression, inhibiting early stages of tumor growth, through immunosurveillance while facilitating later stages of tumor progression. Recent findings have revealed that activated CD8 T cells can stimulate mammary epithelial tumor cells to undergo epithelial-mesenchymal transition (EMT) and to acquire the greatly increased tumorigenic capability and chemotherapeutic resistance of breast cancer stem cells (BCSC). These studies provide a window to understanding how BCSC arise and are maintained within tumors, and how to best target these processes for therapeutic benefit.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Association for Cancer Research
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom3005
dc.relation.ispartofpageto3008
dc.relation.ispartofissue8
dc.relation.ispartofjournalCancer Research
dc.relation.ispartofvolume70
dc.rights.retentionY
dc.subject.fieldofresearchTumour Immunology
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode110709
dc.subject.fieldofresearchcode1112
dc.titleImmune promotion of epithelial-mesenchymal transition and generation of breast cancer stem cells
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorReiman, Jennifer M.


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