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dc.contributor.authorJohnston, Barbara M
dc.contributor.authorJohnston, Peter R
dc.date.accessioned2018-06-20T01:24:09Z
dc.date.available2018-06-20T01:24:09Z
dc.date.issued2017
dc.identifier.issn2325-8861
dc.identifier.doi10.22489/CinC.2017.268-024
dc.identifier.urihttp://hdl.handle.net/10072/377068
dc.description.abstractElevation and depression in the ST segment of the electrocardiogram is commonly used as part of a diagnosis of myocardial ischaemia, although there is not yet a clear correlation between these observations and partial thickness ischaemia. In this work, we use a half-ellipsoid bidomain model of subendocardial ischaemia in a ventricle to study the effect of changes in model parameters on ST segment epicardial potential distributions (EPDs). We use generalised polynomial chaos techniques to produce mean EPDs, where the six bidomain conductivity values are varied, as well as blood conductivity and fibre rotation, for a number of different representations of the ischaemic region. We find that, as the thickness of the ischaemic region (i.e. the ischaemic depth) increases, the character of the mean EPD first changes from a single minimum approximately above the ischaemic region, to a maximum over the ischaemic region, with the minimum moving to a border of the ischaemic region. Next a second minimum develops, in addition to the previous maximum and minimum. In contrast, the strength of the maximum and the minima is only affected in a minor way by changes in the width of the ischaemic border and the position of the ischaemic region, provided it is not near the apex or base of the ventricle. When the size of the ischaemic region is increased, the magnitudes of both the maximum and the minima increase, but their character does not change. In summary, the qualitative progression of the mean EPD with increasing ischaemic depth, from single minimum through to a maximum surrounded by two minima, is the same, regardless of the size and position of the ischaemic region.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherComputing in Cardiology (CinC)
dc.publisher.placeUnited States
dc.relation.ispartofconferencename44th Computing in Cardiology Conference (CinC)
dc.relation.ispartofconferencetitle2017 COMPUTING IN CARDIOLOGY (CINC)
dc.relation.ispartofdatefrom2017-09-24
dc.relation.ispartofdateto2017-09-27
dc.relation.ispartoflocationRennes, FRANCE
dc.relation.ispartofpagefrom4 pages
dc.relation.ispartofpageto4 pages
dc.relation.ispartofvolume44
dc.subject.fieldofresearchBiological mathematics
dc.subject.fieldofresearchcode490102
dc.titleUsing generalised polynomial chaos to examine various parameters in a half-ellipsoidal ventricular model of partial thickness ischaemia
dc.typeConference output
dc.type.descriptionE1 - Conferences
dc.type.codeE - Conference Publications
gro.facultyGriffith Sciences, School of Natural Sciences
gro.rights.copyright© 2017 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
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gro.griffith.authorJohnston, Barbara M.
gro.griffith.authorJohnston, Peter R.


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