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  • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

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    Author(s)
    Turcot, Valerie
    Lu, Yingchang
    Highland, Heather M
    Schurmann, Claudia
    Justice, Anne E
    Fine, Rebecca S
    Bradfield, Jonathan P
    Esko, Tonu
    Giri, Ayush
    Graff, Mariaelisa
    Guo, Xiuqing
    Hendricks, Audrey E
    Karaderi, Tugce
    Lempradl, Adelheid
    Locke, Adam E
    Mahajan, Anubha
    Marouli, Eirini
    Sivapalaratnam, Suthesh
    Young, Kristin L
    Alfred, Tamuno
    Feitosa, Mary F
    Masca, Nicholas GD
    Manning, Alisa K
    Medina-Gomez, Carolina
    Mudgal, Poorva
    Ng, Maggie CY
    Reiner, Alex P
    Vedantam, Sailaja
    Willems, Sara M
    Winkler, Thomas W
    Abecasis, Goncalo
    Aben, Katja K
    Alam, Dewan S
    Alharthi, Sameer E
    Allison, Matthew
    Amouyel, Philippe
    Asselbergs, Folkert W
    Auer, Paul L
    Balkau, Beverley
    Bang, Lia E
    Barroso, Ines
    Bastarache, Lisa
    Benn, Marianne
    Bergmann, Sven
    Bielak, Lawrence F
    Blueher, Matthias
    Boehnke, Michael
    Boeing, Heiner
    Boerwinkle, Eric
    Boeger, Carsten A
    Bork-Jensen, Jette
    Bots, Michiel L
    Bottinger, Erwin P
    Bowden, Donald W
    Brandslund, Ivan
    Breen, Gerome
    Brilliant, Murray H
    Broer, Linda
    Brumat, Marco
    Burt, Amber A
    Butterworth, Adam S
    Campbell, Peter T
    Cappellani, Stefania
    Carey, David J
    Catamo, Eulalia
    Caulfield, Mark J
    Chambers, John C
    Chasman, Daniel I
    Chen, Yii-Der I
    Chowdhury, Rajiv
    Christensen, Cramer
    Chu, Audrey Y
    Cocca, Massimiliano
    Collins, Francis S
    Cook, James P
    Corley, Janie
    Galbany, Jordi Corominas
    Cox, Amanda J
    Crosslin, David S
    Cuellar-Partida, Gabriel
    D'Eustacchio, Angela
    Danesh, John
    Davies, Gail
    Bakker, Paul IW
    Groot, Mark CH
    Mutsert, Renee
    Deary, Ian J
    Dedoussis, George
    Demerath, Ellen W
    Heijer, Martin
    Hollander, Anneke I
    Ruijter, Hester M
    Dennis, Joe G
    Denny, Josh C
    Angelantonio, Emanuele
    Drenos, Fotios
    Du, Mengmeng
    Dube, Marie-Pierre
    Dunning, Alison M
    Easton, Douglas F
    Edwards, Todd L
    Ellinghaus, David
    Ellinor, Patrick T
    Elliott, Paul
    Evangelou, Evangelos
    Farmaki, Aliki-Eleni
    Farooqi, I Sadaf
    Faul, Jessica D
    Fauser, Sascha
    Feng, Shuang
    Ferrannini, Ele
    Ferrieres, Jean
    Florez, Jose C
    Ford, Ian
    Fornage, Myriam
    Franco, Oscar H
    Franke, Andre
    Franks, Paul W
    Friedrich, Nele
    Frikke-Schmidt, Ruth
    Galesloot, Tessel E
    Gan, Wei
    Gandin, Ilaria
    Gasparini, Paolo
    Gibson, Jane
    Giedraitis, Vilmantas
    Gjesing, Anette P
    Gordon-Larsen, Penny
    Gorski, Mathias
    Grabe, Hans-Joergen
    Grant, Struan FA
    Grarup, Niels
    Griffiths, Helen L
    Grove, Megan L
    Gudnason, Vilmundur
    Gustafsson, Stefan
    Haessler, Jeff
    Hakonarson, Hakon
    Hammerschlag, Anke R
    Hansen, Torben
    Harris, Kathleen Mullan
    Harris, Tamara B
    Hattersley, Andrew T
    Have, Christian T
    Hayward, Caroline
    He, Liang
    Heard-Costa, Nancy L
    Heath, Andrew C
    Heid, Iris M
    Helgeland, Oyvind
    Hernesniemi, Jussi
    Hewitt, Alex W
    Holmen, Oddgeir L
    Hovingh, G Kees
    Howson, Joanna MM
    Hu, Yao
    Huang, Paul L
    Huffman, Jennifer E
    Ikram, M Arfan
    Ingelsson, Erik
    Jackson, Anne U
    Jansson, Jan-Hakan
    Jarvik, Gail P
    Jensen, Gorm B
    Jia, Yucheng
    Johansson, Stefan
    Jorgensen, Marit E
    Jorgensen, Torben
    Jukema, J Wouter
    Kahali, Bratati
    Kahn, Rene S
    Kahonen, Mika
    Kamstrup, Pia R
    Kanoni, Stavroula
    Kaprio, Jaakko
    Karaleftheri, Maria
    Kardia, Sharon LR
    Karpe, Fredrik
    Kathiresan, Sekar
    Kee, Frank
    Kiemeney, Lambertus A
    Kim, Eric
    Kitajima, Hidetoshi
    Komulainen, Pirjo
    Kooner, Jaspal S
    Kooperberg, Charles
    Korhonen, Tellervo
    Kovacs, Peter
    Kuivaniemi, Helena
    Kutalik, Zoltan
    Kuulasmaa, Kari
    Kuusisto, Johanna
    Laakso, Markku
    Lakka, Timo A
    Lamparter, David
    Lange, Ethan M
    Lange, Leslie A
    Langenberg, Claudia
    Larson, Eric B
    Lee, Nanette R
    Lehtimaki, Terho
    Lewis, Cora E
    Li, Huaixing
    Li, Jin
    Li-Gao, Ruifang
    Lin, Honghuang
    Lin, Keng-Hung
    Lin, Li-An
    Lin, Xu
    Lind, Lars
    Lindstrom, Jaana
    Linneberg, Allan
    Liu, Ching-Ti
    Liu, Dajiang J
    Liu, Yongmei
    Lo, Ken S
    Lophatananon, Artitaya
    Lotery, Andrew J
    Loukola, Anu
    Luan, Jian'an
    Lubitz, Steven A
    Lyytikainen, Leo-Pekka
    Mannisto, Satu
    Marenne, Gaelle
    Mazul, Angela L
    McCarthy, Mark I
    McKean-Cowdin, Roberta
    Medland, Sarah E
    Meidtner, Karina
    Milani, Lili
    Mistry, Vanisha
    Mitchell, Paul
    Mohlke, Karen L
    Moilanen, Leena
    Moitry, Marie
    Montgomery, Grant W
    Mook-Kanamori, Dennis O
    Moore, Carmel
    Mori, Trevor A
    Morris, Andrew D
    Morris, Andrew P
    Mueller-Nurasyid, Martina
    Munroe, Patricia B
    Nalls, Mike A
    Narisu, Narisu
    Nelson, Christopher P
    Neville, Matt
    Nielsen, Sune F
    Nikus, Kjell
    Njolstad, Pal R
    Nordestgaard, Borge G
    Nyholt, Dale R
    O'Connel, Jeffrey R
    O'Donoghue, Michelle L
    Loohuis, Loes M Olde
    Ophoff, Roel A
    Owen, Katharine R
    Packard, Chris J
    Padmanabhan, Sandosh
    Palmer, Colin NA
    Palmer, Nicholette D
    Pasterkamp, Gerard
    Patel, Aniruddh P
    Pattie, Alison
    Pedersen, Oluf
    Peissig, Peggy L
    Peloso, Gina M
    Pennell, Craig E
    Perola, Markus
    Perry, James A
    Perry, John RB
    Pers, Tune H
    Person, Thomas N
    Peters, Annette
    Petersen, Eva RB
    Peyser, Patricia A
    Pirie, Ailith
    Polasek, Ozren
    Polderman, Tinca J
    Puolijoki, Hannu
    Raitakari, Olli T
    Rasheed, Asif
    Rauramaa, Rainer
    Reilly, Dermot F
    Renstrom, Frida
    Rheinberger, Myriam
    Ridker, Paul M
    Rioux, John D
    Rivas, Manuel A
    Roberts, David J
    Robertson, Neil R
    Robino, Antonietta
    Rolandsson, Olov
    Rudan, Igor
    Ruth, Katherine S
    Saleheen, Danish
    Salomaa, Veikko
    Samani, Nilesh J
    Sapkota, Yadav
    Sattar, Naveed
    Schoen, Robert E
    Schreiner, Pamela J
    Schulze, Matthias B
    Scott, Robert A
    Segura-Lepe, Marcelo P
    Shah, Svati H
    Sheu, Wayne H-H
    Sim, Xueling
    Slater, Andrew J
    Small, Kerrin S
    Smith, Albert V
    Southam, Lorraine
    Spector, Timothy D
    Speliotes, Elizabeth K
    Starr, John M
    Stefansson, Kari
    Steinthorsdottir, Valgerdur
    Stirrups, Kathleen E
    Strauch, Konstantin
    Stringham, Heather M
    Stumvoll, Michael
    Sun, Liang
    Surendran, Praveen
    Swift, Amy J
    Tada, Hayato
    Tansey, Katherine E
    Tardif, Jean-Claude
    Taylor, Kent D
    Teumer, Alexander
    Thompson, Deborah J
    Thorleifsson, Gudmar
    Thorsteinsdottir, Unnur
    Thuesen, Betina H
    Toenjes, Anke
    Tromp, Gerard
    Trompet, Stella
    Tsafantakis, Emmanouil
    Tuomilehto, Jaakko
    Tybjaerg-Hansen, Anne
    Tyrer, Jonathan P
    Uher, Rudolf
    Uitterlinden, Andre G
    Uusitupa, Matti
    Laan, Sander W
    Duijn, Cornelia M
    Leeuwen, Nienke
    van Setten, Jessica
    Vanhala, Mauno
    Varbo, Anette
    Varga, Tibor V
    Varma, Rohit
    Edwards, Digna R Velez
    Vermeulen, Sita H
    Veronesi, Giovanni
    Vestergaard, Henrik
    Vitart, Veronique
    Vogt, Thomas F
    Voelker, Uwe
    Vuckovic, Dragana
    Wagenknecht, Lynne E
    Walker, Mark
    Wallentin, Lars
    Wang, Feijie
    Wang, Carol A
    Wang, Shuai
    Wang, Yiqin
    Ware, Erin B
    Wareham, Nicholas J
    Warren, Helen R
    Waterworth, Dawn M
    Wessel, Jennifer
    White, Harvey D
    Willer, Cristen J
    Wilson, James G
    Witte, Daniel R
    Wood, Andrew R
    Wu, Ying
    Yaghootkar, Hanieh
    Yao, Jie
    Yao, Pang
    Yerges-Armstrong, Laura M
    Young, Robin
    Zeggini, Eleftheria
    Zhan, Xiaowei
    Zhang, Weihua
    Zhao, Jing Hua
    Zhao, Wei
    Zhou, Wei
    Zondervan, Krina T
    Rotter, Jerome I
    Pospisilik, John A
    Rivadeneira, Fernando
    Borecki, Ingrid B
    Deloukas, Panos
    Frayling, Timothy M
    Lettre, Guillaume
    North, Kari E
    Lindgren, Cecilia M
    Hirschhorn, Joel N
    Loos, Ruth JF
    Griffith University Author(s)
    Cox, Amanda J.
    Year published
    2018
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    Show full item record
    Abstract
    Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and ...
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    Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. The effect sizes of rare variants are ~10 times larger than those of common variants, with the largest effect observed in carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed ~7 kg more than non-carriers. Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
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    Journal Title
    Nature Genetics
    Volume
    50
    DOI
    https://doi.org/10.1038/s41588-017-0011-x
    Copyright Statement
    © 2018 Nature Publishing Group. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
    Subject
    Biological sciences
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/377154
    Collection
    • Journal articles

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      Background Hip fractures are a common type of fragility fracture that afflict 293,000 Americans (over 5,000 per week) and 35,000 Canadians (over 670 per week) annually. Despite the large population impact the optimal ...
      JOURNAL ARTICLE
    • Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990—2010: a systematic analysis for the Global Burden of Disease Study 2010 

      Murray, Christopher JL; Vos, Theo; Lozano, Rafael; Naghavi, Mohsen; Flaxman, Abraham D; Michaud, Catherine; Ezzati, Majid; Shibuya, Kenji; Salomon, Joshua A; Abdalla, Safa; Aboyans, Victor; Abraham, Jerry; Ackerman, Ilana; Aggarwal, Rakesh; Ahn, Stephanie Y; Ali, Mohammed K; Alvarado, Miriam; Anderson, H Ross; Anderson, Laurie M; Andrews, Kathryn G; Atkinson, Charles; Baddour, Larry M; Bahalim, Adil N; Barker-Collo, Suzanne; Barrero, Lope H; Bartels, David H; Basanez, Maria-Gloria; Baxter, Amanda; Bell, Michelle L; Benjamin, Emelia J; Bennett, Derrick; Bernabe, Eduardo; Bhalla, Kavi; Bhandari, Bishal; Bikbov, Boris; Bin Abdulhak, Aref; Birbeck, Gretchen; Black, James A; Blencowe, Hannah; Blore, Jed D; Blyth, Fiona; Bolliger, Ian; Bonaventure, Audrey; Boufous, Soufi Ane; Bourne, Rupert; Boussinesq, Michel; Braithwaite, Tasanee; Brayne, Carol; Bridgett, Lisa; Brooker, Simon; Brooks, Peter; Brugha, Traolach S; Bryan-Hancock, Claire; Bucello, Chiara; Buchbinder, Rachelle; Buckle, Geoffrey; Budke, Christine M; Burch, Michael; Burney, Peter; Burstein, Roy; Calabria, Bianca; Campbell, Benjamin; Canter, Charles E; Carabin, Helene; Carapetis, Jonathan; Carmona, Loreto; Cella, Claudia; Charlson, Fiona; Chen, Honglei; Cheng, Andrew Tai-Ann; Chou, David; Chugh, Sumeet S; Coffeng, Luc E; Colan, Steven D; Colquhoun, Samantha; Colson, K Ellicott; Condon, John; Connor, Myles D; Cooper, Leslie T; Corriere, Matthew; Cortinovis, Monica; De Vaccaro, Karen Courville; Couser, William; Cowie, Benjamin C; Criqui, Michael H; Cross, Marita; Dabhadkar, Kaustubh C; Dahiya, Manu; Dahodwala, Nabila; Damsere-Derry, James; Danaei, Goodarz; Davis, Adrian; De Leo, Diego; Degenhardt, Louisa; Dellavalle, Robert; Delossantos, Allyne; Denenberg, Julie; Derrett, Sarah; Des Jarlais, Don C; Dharmaratne, Samath D; Dherani, Mukesh; Diaz-Torne, Cesar; Dolk, Helen; Dorsey, E Ray; Driscoll, Tim; Duber, Herbert; Ebel, Beth; Edmond, Karen; Elbaz, Alexis; Ali, Suad Eltahir; Erskine, Holly; Erwin, Patricia J; Espindola, Patricia; Ewoigbokhan, Stalin E; Farzadfar, Farshad; Feigin, Valery; Felson, David T; Ferrari, Alize; Ferri, Cleusa P; Fevre, Eric M; Finucane, Mariel M; Flaxman, Seth; Flood, Louise; Foreman, Kyle; Forouzanfar, Mohammad H; Fowkes, Francis Gerry R; Fransen, Marlene; Freeman, Michael K; Gabbe, Belinda J; Gabriel, Sherine E; Gakidou, Emmanuela; Ganatra, Hammad A; Garcia, Bianca; Gaspari, Flavio; Gillum, Richard F; Gmel, Gerhard; Gonzalez-Medina, Diego; Gosselin, Richard; Grainger, Rebecca; Grant, Bridget; Groeger, Justina; Guillemin, Francis; Gunnell, David; Gupta, Ramyani; Haagsma, Juanita; Hagan, Holly; Halasa, Yara A; Hall, Wayne; Haring, Diana; Maria Haro, Josep; Harrison, James E; Havmoeller, Rasmus; Hay, Roderick J; Higashi, Hideki; Hill, Catherine; Hoen, Bruno; Hoffman, Howard; Hotez, Peter J; Hoy, Damian; Huang, John J; Ibeanusi, Sydney E; Jacobsen, Kathryn H; James, Spencer L; Jarvis, Deborah; Jasrasaria, Rashmi; Jayaraman, Sudha; Johns, Nicole; Jonas, Jost B; Karthikeyan, Ganesan; Kassebaum, Nicholas; Kawakami, Norito; Keren, Andre; Khoo, Jon-Paul; King, Charles H; Knowlton, Lisa Marie; Kobusingye, Olive; Koranteng, Adofo; Krishnamurthi, Rita; Laden, Francine; Lalloo, Ratilal; Laslett, Laura L; Lathlean, Tim; Leasher, Janet L; Lee, Yong Yi; Leigh, James; Levinson, Daphna; Lim, Stephen S; Limb, Elizabeth; Lin, John Kent; Lipnick, Michael; Lipshultz, Steven E; Liu, Wei; Loane, Maria; Ohno, Summer Lockett; Lyons, Ronan; Mabweijano, Jacqueline; MacIntyre, Michael F; Malekzadeh, Reza; Mallinger, Leslie; Manivannan, Sivabalan; Marcenes, Wagner; March, Lyn; Margolis, David J; Marks, Guy B; Marks, Robin; Matsumori, Akira; Matzopoulos, Richard; Mayosi, Bongani M; McAnulty, John H; McDermott, Mary M; McGill, Neil; McGrath, John; Elena Medina-Mora, Maria; Meltzer, Michele; Mensah, George A; Merriman, Tony R; Meyer, Ana-Claire; Miglioli, Valeria; Miller, Matthew; Miller, Ted R; Mitchell, Philip B; Mock, Charles; Mocumbi, Ana Olga; Moffitt, Terrie E; Mokdad, Ali A; Monasta, Lorenzo; Montico, Marcella; Moradi-Lakeh, Maziar; Moran, Andrew; Morawska, Lidia; Mori, Rintaro; Murdoch, Michele E; Mwaniki, Michael K; Naidoo, Kovin; Nair, M Nathan; Naldi, Luigi; Narayan, KM Venkat; Nelson, Paul K; Nelson, Robert G; Nevitt, Michael C; Newton, Charles R; Nolte, Sandra; Norman, Paul; Norman, Rosana; O'Donnell, Martin; O'Hanlon, Simon; Olives, Casey; Omer, Saad B; Ortblad, Katrina; Osborne, Richard; Ozgediz, Doruk; Page, Andrew; Pahari, Bishnu; Pandian, Jeyaraj Durai; Panozo Rivero, Andrea; Patten, Scott B; Pearce, Neil; Perez Padilla, Rogelio; Perez-Ruiz, Fernando; Perico, Norberto; Pesudovs, Konrad; Phillips, David; Phillips, Michael R; Pierce, Kelsey; Pion, Sebastien; Polanczyk, Guilherme V; Polinder, Suzanne; Pope, C Arden; Popova, Svetlana; Porrini, Esteban; Pourmalek, Farshad; Prince, Martin; Pullan, Rachel L; Ramaiah, Kapa D; Ranganathan, Dharani; Razavi, Homie; Regan, Mathilda; Rehm, Juergen T; Rein, David B; Remuzzi, Guiseppe; Richardson, Kathryn; Rivara, Frederick P; Roberts, Thomas; Robinson, Carolyn; Rodriguez De Leon, Felipe; Ronfani, Luca; Room, Robin; Rosenfeld, Lisa C; Rushton, Lesley; Sacco, Ralph L; Saha, Sukanta; Sampson, Uchechukwu; Sanchez-Riera, Lidia; Sanman, Ella; Schwebel, David C; Scott, James Graham; Segui-Gomez, Maria; Shahraz, Saeid; Shepard, Donald S; Shin, Hwashin; Shivakoti, Rupak; Singh, David; Singh, Gitanjali M; Singh, Jasvinder A; Singleton, Jessica; Sleet, David A; Sliwa, Karen; Smith, Emma; Smith, Jennifer L; Stapelberg, Nicolas JC; Steer, Andrew; Steiner, Timothy; Stolk, Wilma A; Stovner, Lars Jacob; Sudfeld, Christopher; Syed, Sana; Tamburlini, Giorgio; Tavakkoli, Mohammad; Taylor, Hugh R; Taylor, Jennifer A; Taylor, William J; Thomas, Bernadette; Thomson, W Murray; Thurston, George D; Tleyjeh, Imad M; Tonelli, Marcello; Towbin, Jeff Rey A; Truelsen, Thomas; Tsilimbaris, Miltiadis K; Ubeda, Clotilde; Undurraga, Eduardo A; van der Werf, Marieke J; van Os, Jim; Vavilala, Monica S; Venketasubramanian, N; Wang, Mengru; Wang, Wenzhi; Watt, Kerrianne; Weatherall, David J; Weinstock, Martin A; Weintraub, Robert; Weisskopf, Marc G; Weissman, Myrna M; White, Richard A; Whiteford, Harvey; Wiebe, Natasha; Wiersma, Steven T; Wilkinson, James D; Williams, Hywel C; Williams, Sean RM; Witt, Emma; Wolfe, Frederick; Woolf, Anthony D; Wulf, Sarah; Yeh, Pon-Hsiu; Zaidi, Anita KM; Zheng, Zhi-Jie; Zonies, David; Lopez, Alan D (The Lancet, 2012)
      Background Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed ...
      JOURNAL ARTICLE
    • Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990—2010: a systematic analysis for the Global Burden of Disease Study 2010 

      Vos, Theo; Flaxman, Abraham D; Naghavi, Mohsen; Lozano, Rafael; Michaud, Catherine; Ezzati, Majid; Shibuya, Kenji; Salomon, Joshua A; Abdalla, Safa; Aboyans, Victor; Abraham, Jerry; Ackerman, Ilana; Aggarwal, Rakesh; Ahn, Stephanie Y; Ali, Mohammed K; Alvarado, Miriam; Anderson, H Ross; Anderson, Laurie M; Andrews, Kathryn G; Atkinson, Charles; Baddour, Larry M; Bahalim, Adil N; Barker-Collo, Suzanne; Barrero, Lope H; Bartels, David H; Basanez, Maria-Gloria; Baxter, Amanda; Bell, Michelle L; Benjamin, Emelia J; Bennett, Derrick; Bernabe, Eduardo; Bhalla, Kavi; Bhandari, Bishal; Bikbov, Boris; Bin Abdulhak, Aref; Birbeck, Gretchen; Black, James A; Blencowe, Hannah; Blore, Jed D; Blyth, Fiona; Bolliger, Ian; Bonaventure, Audrey; Boufous, Soufi Ane; Bourne, Rupert; Boussinesq, Michel; Braithwaite, Tasanee; Brayne, Carol; Bridgett, Lisa; Brooker, Simon; Brooks, Peter; Brugha, Traolach S; Bryan-Hancock, Claire; Bucello, Chiara; Buchbinder, Rachelle; Buckle, Geoff Rey; Budke, Christine M; Burch, Michael; Burney, Peter; Burstein, Roy; Calabria, Bianca; Campbell, Benjamin; Canter, Charles E; Carabin, Helene; Carapetis, Jonathan; Carmona, Loreto; Cella, Claudia; Charlson, Fiona; Chen, Honglei; Cheng, Andrew Tai-Ann; Chou, David; Chugh, Sumeet S; Coffeng, Luc E; Colan, Steven D; Colquhoun, Samantha; Colson, K Ellicott; Condon, John; Connor, Myles D; Cooper, Leslie T; Corriere, Matthew; Cortinovis, Monica; de Vaccaro, Karen Courville; Couser, William; Cowie, Benjamin C; Criqui, Michael H; Cross, Marita; Dabhadkar, Kaustubh C; Dahiya, Manu; Dahodwala, Nabila; Damsere-Derry, James; Danaei, Goodarz; Davis, Adrian; De Leo, Diego; Degenhardt, Louisa; Dellavalle, Robert; Delossantos, Allyne; Denenberg, Julie; Derrett, Sarah; Des Jarlais, Don C; Dharmaratne, Samath D; Dherani, Mukesh; Diaz-Torne, Cesar; Dolk, Helen; Dorsey, E Ray; Driscoll, Tim; Duber, Herbert; Ebel, Beth; Edmond, Karen; Elbaz, Alexis; Ali, Suad Eltahir; Erskine, Holly; Erwin, Patricia J; Espindola, Patricia; Ewoigbokhan, Stalin E; Farzadfar, Farshad; Feigin, Valery; Felson, David T; Ferrari, Alize; Ferri, Cleusa P; Fevre, Eric M; Finucane, Mariel M; Flaxman, Seth; Flood, Louise; Foreman, Kyle; Forouzanfar, Mohammad H; Fowkes, Francis Gerry R; Franklin, Richard; Fransen, Marlene; Freeman, Michael K; Gabbe, Belinda J; Gabriel, Sherine E; Gakidou, Emmanuela; Ganatra, Hammad A; Garcia, Bianca; Gaspari, Flavio; Gillum, Richard F; Gmel, Gerhard; Gosselin, Richard; Grainger, Rebecca; Groeger, Justina; Guillemin, Francis; Gunnell, David; Gupta, Ramyani; Haagsma, Juanita; Hagan, Holly; Halasa, Yara A; Hall, Wayne; Haring, Diana; Maria Haro, Josep; Harrison, James E; Havmoeller, Rasmus; Hay, Roderick J; Higashi, Hideki; Hill, Catherine; Hoen, Bruno; Hoffman, Howard; Hotez, Peter J; Hoy, Damian; Huang, John J; Ibeanusi, Sydney E; Jacobsen, Kathryn H; James, Spencer L; Jarvis, Deborah; Jasrasaria, Rashmi; Jayaraman, Sudha; Johns, Nicole; Jonas, Jost B; Karthikeyan, Ganesan; Kassebaum, Nicholas; Kawakami, Norito; Keren, Andre; Khoo, Jon-Paul; King, Charles H; Knowlton, Lisa Marie; Kobusingye, Olive; Koranteng, Adofo; Krishnamurthi, Rita; Lalloo, Ratilal; Laslett, Laura L; Lathlean, Tim; Leasher, Janet L; Lee, Yong Yi; Leigh, James; Lim, Stephen S; Limb, Elizabeth; Lin, John Kent; Lipnick, Michael; Lipshultz, Steven E; Liu, Wei; Loane, Maria; Ohno, Summer Lockett; Lyons, Ronan; Ma, Jixiang; Mabweijano, Jacqueline; MacIntyre, Michael F; Malekzadeh, Reza; Mallinger, Leslie; Manivannan, Sivabalan; Marcenes, Wagner; March, Lyn; Margolis, David J; Marks, Guy B; Marks, Robin; Matsumori, Akira; Matzopoulos, Richard; Mayosi, Bongani M; McAnulty, John H; McDermott, Mary M; McGill, Neil; McGrath, John; Elena Medina-Mora, Maria; Meltzer, Michele; Mensah, George A; Merriman, Tony R; Meyer, Ana-Claire; Miglioli, Valeria; Miller, Matthew; Miller, Ted R; Mitchell, Philip B; Mocumbi, Ana Olga; Moffitt, Terrie E; Mokdad, Ali A; Monasta, Lorenzo; Montico, Marcella; Moradi-Lakeh, Maziar; Moran, Andrew; Morawska, Lidia; Mori, Rintaro; Murdoch, Michele E; Mwaniki, Michael K; Naidoo, Kovin; Nair, M Nathan; Naldi, Luigi; Narayan, KM Venkat; Nelson, Paul K; Nelson, Robert G; Nevitt, Michael C; Newton, Charles R; Nolte, Sandra; Norman, Paul; Norman, Rosana; O'Donnell, Martin; O'Hanlon, Simon; Olives, Casey; Omer, Saad B; Ortblad, Katrina; Osborne, Richard; Ozgediz, Doruk; Page, Andrew; Pahari, Bishnu; Pandian, Jeyaraj Durai; Rivero, Andrea Panozo; Patten, Scott B; Pearce, Neil; Perez Padilla, Rogelio; Perez-Ruiz, Fernando; Perico, Norberto; Pesudovs, Konrad; Phillips, David; Phillips, Michael R; Pierce, Kelsey; Pion, Sebastien; Polanczyk, Guilherme V; Polinder, Suzanne; Pope, C Arden; Popova, Svetlana; Porrini, Esteban; Pourmalek, Farshad; Prince, Martin; Pullan, Rachel L; Ramaiah, Kapa D; Ranganathan, Dharani; Razavi, Homie; Regan, Mathilda; Rehm, Juergen T; Rein, David B; Remuzzi, Guiseppe; Richardson, Kathryn; Rivara, Frederick P; Roberts, Thomas; Robinson, Carolyn; De Leon, Felipe Rodriguez; Ronfani, Luca; Room, Robin; Rosenfeld, Lisa C; Rushton, Lesley; Sacco, Ralph L; Saha, Sukanta; Sampson, Uchechukwu; Sanchez-Riera, Lidia; Sanman, Ella; Schwebel, David C; Scott, James Graham; Segui-Gomez, Maria; Shahraz, Saeid; Shepard, Donald S; Shin, Hwashin; Shivakoti, Rupak; Singh, David; Singh, Gitanjali M; Singh, Jasvinder A; Singleton, Jessica; Sleet, David A; Sliwa, Karen; Smith, Emma; Smith, Jennifer L; Stapelberg, Nicolas JC; Steer, Andrew; Steiner, Timothy; Stolk, Wilma A; Stovner, Lars Jacob; Sudfeld, Christopher; Syed, Sana; Tamburlini, Giorgio; Tavakkoli, Mohammad; Taylor, Hugh R; Taylor, Jennifer A; Taylor, William J; Thomas, Bernadette; Thomson, W Murray; Thurston, George D; Tleyjeh, Imad M; Tonelli, Marcello; Towbin, Jeff Rey A; Truelsen, Thomas; Tsilimbaris, Miltiadis K; Ubeda, Clotilde; Undurraga, Eduardo A; van der Werf, Marieke J; van Os, Jim; Vavilala, Monica S; Venketasubramanian, N; Wang, Mengru; Wang, Wenzhi; Watt, Kerrianne; Weatherall, David J; Weinstock, Martin A; Weintraub, Robert; Weisskopf, Marc G; Weissman, Myrna M; White, Richard A; Whiteford, Harvey; Wiersma, Steven T; Wilkinson, James D; Williams, Hywel C; Williams, Sean RM; Witt, Emma; Wolfe, Frederick; Woolf, Anthony D; Wulf, Sarah; Yeh, Pon-Hsiu; Zaidi, Anita KM; Zheng, Zhi-Jie; Zonies, David; Lopez, Alan D; Murray, Christopher JL (The Lancet, 2012)
      Background Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and ...
      JOURNAL ARTICLE

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