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dc.contributor.authorOdenthal, C
dc.contributor.authorSimpson, S
dc.contributor.authorOughton, J
dc.contributor.authorvan der Mei, I
dc.contributor.authorRose, S
dc.contributor.authorFripp, J
dc.contributor.authorLucas, R
dc.contributor.authorTaylor, B
dc.contributor.authorDear, K
dc.contributor.authorPonsonby, AL
dc.contributor.authorCoulthard, A
dc.contributor.authorChapman, C
dc.contributor.authorDwyer, T
dc.contributor.authorKilpatrick, T
dc.contributor.authorMcMichael, T
dc.contributor.authorPender, MP
dc.contributor.authorValery, P
dc.contributor.authorWilliams, D
dc.contributor.authorBroadley, S
dc.contributor.authorLechner-Scott, J
dc.contributor.authorBlizzard, L
dc.contributor.authorShaw, C
dc.date.accessioned2018-10-29T12:30:36Z
dc.date.available2018-10-29T12:30:36Z
dc.date.issued2017
dc.identifier.issn1754-9477
dc.identifier.doi10.1111/1754-9485.12570
dc.identifier.urihttp://hdl.handle.net/10072/377976
dc.description.abstractIntroduction: Patients presenting with clinically isolated syndrome (CIS) may proceed to clinically definite multiple sclerosis (CDMS). Midsagittal corpus callosum area (CCA) is a surrogate marker for callosal atrophy, and can be obtained from a standard MRI study. This study explores the relationship between CCA measured at CIS presentation (baseline) and at 5 years post presentation, with conversion from CIS to CDMS. The association between CCA and markers of disability progression is explored. Methods: Corpus callosum area was measured on MRI scans at presentation and 5‐year review following diagnosis of a first demyelinating event, or evidence of progressive MS, in 143 participants in the Ausimmune/AusLong Study. Relationships between CCA (at baseline and follow‐up) and clinical outcomes were assessed. Results: Mean CCA at baseline study was 6.63 cm2 (SD 1.01). Patients who converted to MS by 5‐year review (n = 100) had a significantly smaller mean CCA at follow‐up (6.22 vs. 6.74, P = 0.007). Greater CCA reduction was associated with higher annualized relapse rate over follow‐up. Conclusion: Baseline CCA obtained from standard MRI protocols may be compared with subsequent MRI examinations as a surrogate for neurodegeneration and cerebral atrophy in patients with MS. This study demonstrates an association between CCA and disability in individuals presenting with CIS who convert to MS.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherWiley Online
dc.relation.ispartofpagefrom453
dc.relation.ispartofpageto460
dc.relation.ispartofissue4
dc.relation.ispartofjournalJournal of Medical Imaging and Radiation Oncology
dc.relation.ispartofvolume61
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchNursing
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1110
dc.subject.fieldofresearchcode1112
dc.titleMidsagittal corpus callosum area and conversion to multiple sclerosis after clinically isolated syndrome: A multicentre Australian cohort study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorBroadley, Simon


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