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dc.contributor.authorBroadley, Simon
dc.contributor.authorKhalilidehkordi, Ellie
dc.contributor.authorHeshmat, Saman
dc.contributor.authorClarke, Laura
dc.date.accessioned2018-07-16T00:44:35Z
dc.date.available2018-07-16T00:44:35Z
dc.date.issued2017
dc.identifier.issn1473-9348
dc.identifier.urihttp://hdl.handle.net/10072/377978
dc.description.abstractOver the past 13 years neuromyelitis optica spectrum disorder (NMOSD) has emerged as a discrete form of demyelinating disease of the central nervous system in which antibodies against a water channel found in high concentration on astrocytes are frequently found. Following the discovery of this pathogenic antibody the phenotype of this condition, previously known as Devic’s disease, has broadened from one of monophasic or recurrent, optic neuritis and transverse myelitis, to include area postrema lesions, hypothalamic lesions and a fulminant encephalopathic presentation. Clues to the diagnosis include clinical presentations related to the above locations of pathology and imaging changes including longitudinally extensive spinal cord lesions, extensive optic nerve lesions, particularly lesions posterior to or involving the chiasm, and reactive cerebrospinal fluid. Early identification of this disorder is important as the prognosis without treatment is poor and generally worse than is seen in multiple sclerosis (MS). In addition, the approach to treatment (immunosuppression and anti-B-cell therapy) is different to MS and there is a concern that some disease modifying therapies that are helpful in MS may be harmful in NMOSD.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWhitehouse Publishing
dc.publisher.urihttp://www.acnr.co.uk/2017/09/neuromyelitis-optica-spectrum-disorder/
dc.relation.ispartofpagefrom11
dc.relation.ispartofpageto14
dc.relation.ispartofissue1
dc.relation.ispartofjournalAdvances in Clinical Neuroscience and Rehabilitation
dc.relation.ispartofvolume17
dc.subject.fieldofresearchNeurosciences not elsewhere classified
dc.subject.fieldofresearchcode110999
dc.titleNeuromyelitis Optica Spectrum Disorder
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.facultyGriffith Health, School of Medicine
gro.rights.copyright© 2017 Advances in Clinical Neuroscience and Rehabilitation. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorBroadley, Simon
gro.griffith.authorKhalilidehkordi, Ellie


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