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dc.contributor.authorMirshafiey, A
dc.contributor.authorMatsuo, H
dc.contributor.authorRehm, BHA
dc.contributor.authorPourian, EJ
dc.date.accessioned2018-07-11T00:19:35Z
dc.date.available2018-07-11T00:19:35Z
dc.date.issued2004
dc.identifier.issn0165-5728
dc.identifier.doi10.1016/j.jneuroim.2004.06.010
dc.identifier.urihttp://hdl.handle.net/10072/378325
dc.description.abstractThe therapeutic efficacy of M2000 as a novel immunosuppressive and anti-inflammatory agent in T cell-mediated autoimmune disease was tested. The influence of M2000 on myelin basic protein (MBP)-induced experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis was assessed. The onset and symptoms of EAE in Lewis rats could be suppressed by intraperitoneally administration of M- 2000 during the induction phase of disease. Disease suppression was associated with a marked suppression of MBP-specific T cell reactivity in vitro, without any evidence for a generalized impairment of T cell activity. Collectively, our data suggest that M2000 may provide a novel therapeutic option for T cell-mediated autoimmune diseases in animal models and possibly in man.
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom85
dc.relation.ispartofpageto85
dc.relation.ispartofissue1-2
dc.relation.ispartofjournalJournal of Neuroimmunology
dc.relation.ispartofvolume154
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classified
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode060199
dc.subject.fieldofresearchcode1107
dc.subject.fieldofresearchcode1109
dc.titleTreatment of experimental autoimmune encephalomyelitis with M2000, as a novel immunosuppressive agent
dc.typeJournal article
dc.type.descriptionC2 - Articles (Other)
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorRehm, Bernd


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