dc.contributor.author | Mirshafiey, A | |
dc.contributor.author | Matsuo, H | |
dc.contributor.author | Rehm, BHA | |
dc.contributor.author | Pourian, EJ | |
dc.date.accessioned | 2018-07-11T00:19:35Z | |
dc.date.available | 2018-07-11T00:19:35Z | |
dc.date.issued | 2004 | |
dc.identifier.issn | 0165-5728 | |
dc.identifier.doi | 10.1016/j.jneuroim.2004.06.010 | |
dc.identifier.uri | http://hdl.handle.net/10072/378325 | |
dc.description.abstract | The therapeutic efficacy of M2000 as a novel immunosuppressive and anti-inflammatory agent in T cell-mediated autoimmune disease was tested. The influence of M2000 on myelin basic protein (MBP)-induced experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis was assessed. The onset and symptoms of EAE in Lewis rats could be suppressed by intraperitoneally administration of M- 2000 during the induction phase of disease. Disease suppression was associated with a marked suppression of MBP-specific T cell reactivity in vitro, without any evidence for a generalized impairment of T cell activity.
Collectively, our data suggest that M2000 may provide a novel therapeutic option for T cell-mediated autoimmune diseases in animal models and possibly in man. | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofpagefrom | 85 | |
dc.relation.ispartofpageto | 85 | |
dc.relation.ispartofissue | 1-2 | |
dc.relation.ispartofjournal | Journal of Neuroimmunology | |
dc.relation.ispartofvolume | 154 | |
dc.subject.fieldofresearch | Biochemistry and cell biology not elsewhere classified | |
dc.subject.fieldofresearch | Immunology | |
dc.subject.fieldofresearch | Neurosciences | |
dc.subject.fieldofresearchcode | 310199 | |
dc.subject.fieldofresearchcode | 3204 | |
dc.subject.fieldofresearchcode | 3209 | |
dc.title | Treatment of experimental autoimmune encephalomyelitis with M2000, as a novel immunosuppressive agent | |
dc.type | Journal article | |
dc.type.description | C2 - Articles (Other) | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Rehm, Bernd | |