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dc.contributor.authorEl-Deeb, I.en_US
dc.contributor.authorLee, Soen_US
dc.date.accessioned2017-04-04T22:43:19Z
dc.date.available2017-04-04T22:43:19Z
dc.date.issued2010en_US
dc.date.modified2011-07-19T06:25:39Z
dc.identifier.issn0968-0896en_US
dc.identifier.doi10.1016/j.bmc.2010.04.029en_AU
dc.identifier.urihttp://hdl.handle.net/10072/37837
dc.description.abstractA new series of 1H- and 2H-pyrazole derivatives (35 final compounds) has been designed and synthesized in this study. A selected group (13 compounds) was then tested over a panel of 60 cancer cell lines at a single dose concentration of 10 卮 At this concentration, six compounds have showed moderate to strong mean inhibitions, and were further tested at five-dose testing mode to determine their IC50 over the 60 cell lines. The IC50 values of the tested compounds indicated high potency (as for compound 10f) as well as high efficacy (as for compound 11e). Accordingly, compound 10f was then tested at a single dose concentration of 10 占over a panel of 54 kinases to determine its kinase inhibitory profile. The compound has showed good selectivity towards FLT3 kinase, associated with a moderate potency, with an IC50 value of 1.74 卮en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent395707 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationYen_AU
dc.relation.ispartofpagefrom3961en_US
dc.relation.ispartofpageto3973en_US
dc.relation.ispartofissue11en_AU
dc.relation.ispartofjournalBioorganic and Medicinal Chemistryen_US
dc.relation.ispartofvolume18en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchBiologically Active Moleculesen_US
dc.subject.fieldofresearchcode030401en_US
dc.titleDesign and Synthesis of New Potent Anticancer Pyrazoles with High FLT3 Kinase Inhibitory Selectivityen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2010 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_AU
gro.date.issued2010
gro.hasfulltextFull Text


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