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dc.contributor.authorM. Abdel-Aal, Abu-Bakeren_US
dc.contributor.authorZaman, Mehfuzen_US
dc.contributor.authorFujita, Yoshioen_US
dc.contributor.authorF. Good, Michaelen_US
dc.contributor.authorR. Batzloff, Michaelen_US
dc.contributor.authorToth, Istvanen_US
dc.date.accessioned2017-05-03T12:53:58Z
dc.date.available2017-05-03T12:53:58Z
dc.date.issued2010en_US
dc.date.modified2014-01-08T05:28:53Z
dc.identifier.issn00222623en_US
dc.identifier.doi10.1021/jm1007787en_US
dc.identifier.urihttp://hdl.handle.net/10072/37848
dc.description.abstractImmunological assessment of group A streptococcal (GAS) branched lipopeptides demonstrated the impact of spatial arrangement of vaccine components on both the quality and quantity of their immune responses. Each lipopeptide was composed of three components: a GAS B-cell epitope (J14), a universal CD4+ T-cell helper epitope (P25), and an immunostimulant lipid moiety that differs only in its spatial arrangement. The best systemic immune responses were demonstrated by a lipopeptide featuring the lipid moiety at the lipopeptide C-terminus. However, this candidate did not achieve protection against bacterial challenge. The best protection (100%) was shown by a lipopeptide featuring a C-terminal J14, conjugated through a lysine residue to P25 at the N-terminus, and a lipid moiety on the lysine side chain. The former candidate features a-helical conformation required to produce protective J14-specific antibodies. Our results highlight the importance of epitope orientation and lipid position in the design of three-component synthetic vaccines.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherAmerican Chemical Societyen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom8041en_US
dc.relation.ispartofpageto8046en_US
dc.relation.ispartofissue22en_US
dc.relation.ispartofjournalJournal of Medicinal Chemistryen_US
dc.relation.ispartofvolume53en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchInfectious Agentsen_US
dc.subject.fieldofresearchcode060502en_US
dc.titleDesign of three-component vaccines against group A streptococcal infections: importance of spatial arrangement of vaccine componentsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.en_US
gro.date.issued2010
gro.hasfulltextNo Full Text


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