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  • The Immunobiology of viral arthritides

    Author(s)
    Suhrbier, Andreas
    Mahalingam, Suresh
    Griffith University Author(s)
    Mahalingam, Suresh
    Year published
    2009
    Metadata
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    Abstract
    A large range of human viruses are associated with the development of arthritis or arthralgia. Although there are many parallels with autoimmune arthritides, there is little evidence that viral arthritides lead to autoimmune disease. In humans viral arthritides usually last from weeks to months, can be debilitating, and are usually treated with non-steroidal anti-inflammatory drugs, but with variable success. Viral arthritides likely arise from immunopathological inflammatory responses directed at viruses and/or their products residing and/or replicating within joint tissues. Macrophages recruited by monocyte chemoattractant ...
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    A large range of human viruses are associated with the development of arthritis or arthralgia. Although there are many parallels with autoimmune arthritides, there is little evidence that viral arthritides lead to autoimmune disease. In humans viral arthritides usually last from weeks to months, can be debilitating, and are usually treated with non-steroidal anti-inflammatory drugs, but with variable success. Viral arthritides likely arise from immunopathological inflammatory responses directed at viruses and/or their products residing and/or replicating within joint tissues. Macrophages recruited by monocyte chemoattractant protein-1 (MCP-1/CCL2) and activated by interferon, and proinflammatory mediators like tumour necrosis factor a, interferon ?, interleukin-6 and interleukin-1ߠappear to be common elements in this group of diseases. The challenge for new treatments is to target excessive inflammation without compromising anti-viral immunity. Recent evidence from mouse models suggests targeting MCP-1 or complement may emerge as viable new treatment options for viral arthritides.
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    Journal Title
    Pharmacology and Therapeutics
    Volume
    124
    Issue
    3
    DOI
    https://doi.org/10.1016/j.pharmthera.2009.09.005
    Subject
    Medical virology
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/37879
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    • Journal articles

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