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dc.contributor.authorSuhrbier, Andreasen_US
dc.contributor.authorMahalingam, S.en_US
dc.contributor.editorS.J.Ennaen_US
dc.date.accessioned2017-05-03T15:58:58Z
dc.date.available2017-05-03T15:58:58Z
dc.date.issued2009en_US
dc.date.modified2011-03-31T04:46:46Z
dc.identifier.issn01637258en_US
dc.identifier.doi10.1016/j.pharmthera.2009.09.005en_AU
dc.identifier.urihttp://hdl.handle.net/10072/37879
dc.description.abstractA large range of human viruses are associated with the development of arthritis or arthralgia. Although there are many parallels with autoimmune arthritides, there is little evidence that viral arthritides lead to autoimmune disease. In humans viral arthritides usually last from weeks to months, can be debilitating, and are usually treated with non-steroidal anti-inflammatory drugs, but with variable success. Viral arthritides likely arise from immunopathological inflammatory responses directed at viruses and/or their products residing and/or replicating within joint tissues. Macrophages recruited by monocyte chemoattractant protein-1 (MCP-1/CCL2) and activated by interferon, and proinflammatory mediators like tumour necrosis factor a, interferon ?, interleukin-6 and interleukin-1ߠappear to be common elements in this group of diseases. The challenge for new treatments is to target excessive inflammation without compromising anti-viral immunity. Recent evidence from mouse models suggests targeting MCP-1 or complement may emerge as viable new treatment options for viral arthritides.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeUSAen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom301en_US
dc.relation.ispartofpageto308en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalPharmacology and Therapeuticsen_US
dc.relation.ispartofvolume124en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchMedical Virologyen_US
dc.subject.fieldofresearchcode110804en_US
dc.titleThe Immunobiology of viral arthritidesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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