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dc.contributor.authorSantisteban, Martaen_US
dc.contributor.authorM. Reiman, Jenniferen_US
dc.contributor.authorK. Asiedu, Michaelen_US
dc.contributor.authorD. Behrens, Marshallen_US
dc.contributor.authorNassar, Azizaen_US
dc.contributor.authorR. Kalli, Kimberlyen_US
dc.contributor.authorHaluska, Paulen_US
dc.contributor.authorN. Ingle, Jamesen_US
dc.contributor.authorC. Hartmann, Lynnen_US
dc.contributor.authorH. Manjili, Masouden_US
dc.contributor.authorRadisky, Dereken_US
dc.contributor.authorFerrone, Soldanoen_US
dc.contributor.authorKnutson, Keithen_US
dc.date.accessioned2017-05-03T15:57:22Z
dc.date.available2017-05-03T15:57:22Z
dc.date.issued2009en_US
dc.date.modified2011-03-31T04:47:30Z
dc.identifier.issn15387445en_US
dc.identifier.doi10.1158/0008-5472.CAN-08-3343en_AU
dc.identifier.urihttp://hdl.handle.net/10072/37894
dc.description.abstractThe breast cancer stem cell (BCSC) hypotheses suggest that breast cancer is derived from a single tumor-initiating cell with stem-like properties, but the source of these cells is unclear. We previously observed that induction of an immune response against an epithelial breast cancer led in vivo to the T-cell-dependent outgrowth of a tumor, the cells of which had undergone epithelial to mesenchymal transition (EMT). The resulting mesenchymal tumor cells had a CD24-/loCD44+ phenotype, consistent with BCSCs. In the present study, we found that EMT was induced by CD8 T cells and the resulting tumors had characteristics of BCSCs, including potent tumorigenicity, ability to reestablish an epithelial tumor, and enhanced resistance to drugs and radiation. In contrast to the hierarchal cancer stem cell hypothesis, which suggests that breast cancer arises from the transformation of a resident tissue stem cell, our results show that EMT can produce the BCSC phenotype. These findings have several important implications related to disease progression and relapse.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherAmerican Association for Cancer Researchen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationYen_AU
dc.relation.ispartofpagefrom2887en_US
dc.relation.ispartofpageto2895en_US
dc.relation.ispartofissue7en_US
dc.relation.ispartofjournalCancer Researchen_US
dc.relation.ispartofvolume69en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchTumour Immunologyen_US
dc.subject.fieldofresearchcode110709en_US
dc.titleImmune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cellsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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