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dc.contributor.authorJackson, Marken_US
dc.contributor.authorB. Wood, Nigelen_US
dc.contributor.authorZhao, Shunzhien_US
dc.contributor.authorAugst, Alexanderen_US
dc.contributor.authorH. Wolfe, Johnen_US
dc.contributor.authorM.W. Gedroyc, Wladyslawen_US
dc.contributor.authorD. Hughes, Alunen_US
dc.contributor.authorA.McG. Thom, Simonen_US
dc.contributor.authorY. Xu, Xiaoen_US
dc.description.abstractBackground Venous grafts commonly develop myointimal hyperplasia, which can lead to stenoses and, ultimately, with expression of adhesion molecules, lumenal occlusion. The aim of the present study was to investigate whether wall shear stress measured post-operatively would predict subsequent myointimal hypertrophy in lower limb venous bypass grafts. Methods Magnetic resonance imaging and ultrasound were performed in a cohort of patients following lower limb venous bypass graft surgery for peripheral arterial disease at baseline (1-2 weeks) and at follow-up (9-12 months). Wall shear stress was determined at baseline using computational fluid dynamics techniques and intima-media thickness along the length of the graft was measured by ultrasound at baseline and follow up. Results Complete follow-up was possible in eight patients, in whom low wall shear stress at baseline predicted high intima-media thickness. The relationship between wall shear stress (WSS) and intima-media thickness (IMT) was curvilinear with IMT increasing sharply at lower levels of WSS (IMT >1.0 mm at <0.3 Pa). Conclusions Low wall shear stress is associated with subsequent increase in myointimal thickness in lower limb venous bypass grafts. This is believed to be the first prospective study in humans to demonstrate the relationship between low wall shear stress and myointimal thickening and indicates a likely causative role for low wall shear stress in the development of myointimal hyperplasia.en_US
dc.publisherElsevier BVen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofjournalArtery Researchen_US
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classifieden_US
dc.titleLow wall shear stress predicts subsequent development of wall hypertrophy in lower limb bypass graftsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.hasfulltextNo Full Text
gro.griffith.authorJackson, Mark J.

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