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dc.contributor.authorMcGowan, K
dc.contributor.authorIvanovski, S
dc.contributor.authorActon, C
dc.date.accessioned2019-05-29T13:03:47Z
dc.date.available2019-05-29T13:03:47Z
dc.date.issued2018
dc.identifier.issn0045-0421
dc.identifier.doi10.1111/adj.12603
dc.identifier.urihttp://hdl.handle.net/10072/379731
dc.description.abstractBackground: Osteonecrosis of the jaw (ONJ) is a serious complication of both radiation and antiresorptive therapies. This study aimed to determine how many patients have been treated for medication‐related osteonecrosis of the jaws (MRONJ) and osteoradionecrosis (ORN), and whether the number of diagnoses has decreased over time with improved awareness and preventative measures. Methods: Medical records at the Royal Brisbane and Women's Hospital, Gold Coast University Hospital and Robina Hospital were reviewed to identify patients diagnosed with MRONJ and ORN between January 2003 and May 2017. Data on patient demographics, year of admission and primary disease were analysed. Results: Two hundred and thirty‐eight patients were diagnosed with ONJ, of which 74.4% were ORN and 25.6% were MRONJ. Tongue (24.6%), floor of mouth (17.3%) and tonsillar (15.1%) squamous cell carcinomas were the most common primary diseases associated with ORN, with a strong male predominance (80%). Of patients diagnosed with MRONJ, 52.5% were taking low‐dose antiresorptives for osteoporosis (44.2%), rheumatoid arthritis (4.6%) or Paget's disease (3.3%), while 47.5% were oncology patients receiving high‐dose antiresorptives. Conclusions: The number of patients diagnosed with MRONJ and ORN has trended upwards since 2003. ORN affected three times more patients than MRONJ, and patients on low‐dose antiresorptives accounted for over half of the MRONJ cases.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherWiley-Blackwell Publishing
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom202
dc.relation.ispartofpageto207
dc.relation.ispartofissue2
dc.relation.ispartofjournalAustralian Dental Journal
dc.relation.ispartofvolume63
dc.subject.fieldofresearchDentistry not elsewhere classified
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode110599
dc.subject.fieldofresearchcode1105
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1117
dc.titleOsteonecrosis of the jaws: a 14-year retrospective survey of hospital admissions
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionPost-print
gro.facultyAn Unassigned Group, An Unassigned Department
gro.rights.copyright© 2018 Wiley-Liss, Inc. This is the peer reviewed version of the following article: Osteonecrosis of the jaws: a 14-year retrospective survey of hospital admissions, Australian Dental Journal, Vol. 63, Iss. 2, June 2018, pp. 202-207, which has been published in final form at 10.1111/adj.12603. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
gro.hasfulltextFull Text
gro.griffith.authorMcGowan, Kelly M.
gro.griffith.authorIvanovski, Saso


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